Acquisition of resistance to PI3K/AKT-targeted monotherapy implies the existence of common resistance mechanisms independent of cancer type. Here we demonstrate that PI3K/AKT inhibitors cause glycolytic crisis, acetyl-CoA shortage and a global decrease in histone acetylation. Also, PI3K/AKT inhibitors induce drug resistance by selectively augmenting H3K27 acetylation and binding of CBP/p300 and…
A critical goal of vision is to detect changes in light intensity, even when these changes are blurred by the spatial resolution of the eye…
The relationship between personality and brain activity has been an increasingly popular topic of neuroscientific research. However, the limitations of both personality measures and neuroimaging,…
Hog deer are an essential component of Pakistan’s biodiversity. Their conservation helps maintain integrity of local ecosystems, contributing to overall stability and balance of region’s…
Epigenetic deregulation is implied in cancer initiation and resistance to antitumor drugs. In melanoma, aberrant DNA hypermethylation is frequently observed, resulting in the silencing of…
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level…
Motivation: High-throughput technologies have yielded a broad spectrum of multi-omics datasets, offering unparalleled insights into complex biological systems. However, effectively analyzing this diverse array of…
Hypertrophic cardiomyopathy (HCM) is associated with phenotypic variability. To gain insights into transcriptional regulation of cardiac phenotype, single-nucleus linked RNA-/ATAC-seq was performed in 5-week-old control…
Protein solubility plays a crucial role in various biotechnological, industrial and biomedical applications. With the reduction in sequencing and gene synthesis costs, the adoption of…
Gastric Cancer (GC) is a lethal malignancy, with urgent need for the discovery of novel biomarkers for its early detection. I previously showed that Transposable…
Metaproteomics analyzes the functional dynamics of microbial communities by identifying peptides and mapping them to the most likely proteins and taxa. The challenge in this…
