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Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
AbstractPatients with estrogen receptor–positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of…
Gut Microbiome Mediates Ferroptosis Resistance for Colorectal Cancer Development
Abstract. Colorectal cancer is a prevalent cancer type in the United States, affecting both genders and influenced by genetics and environmental factors. The role of…
A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate…
Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
AbstractPatients with estrogen receptor–positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of…
Paradoxical activation of oncogenic signaling as a cancer treatment strategy
Abstract. Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such…
Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues
AbstractPediatric cancers are rare diseases, and children without known germline predisposing conditions who develop a second malignancy during developmental ages are extremely rare. We present…
Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy
Abstract. Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM),…
Solid Tumor CAR-T: Making Progress in Brain Cancer
Abstract: Results from a recently completed phase I trial assessing IL-13Rα2–targeting CAR T cells in high-grade glioma—mainly recurrent glioblastoma—highlight this therapy’s potential, with 29 of…
Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk
AbstractBackground:. High red meat and/or processed meat consumption are established colorectal cancer risk factors. We conducted a genome-wide gene–environment (GxE) interaction analysis to identify genetic…
Mirvetuximab Soravtansine Gets Full Approval
AbbVie announced that its antibody–drug conjugate mirvetuximab soravtansine (Elahere) was granted full approval to treat adults with folate receptor alpha (FRα)—positive, platinum-resistant ovarian cancer who’ve…