The MAPK family of kinases regulates diverse physiological and pathophysiological processes and is inactivated by MAPK phosphatases including MKP5. Blocking MKP5 activity has emerged as a potential treatment for dystrophic muscle disease. Gannam et al . identified and characterized a small molecule that inhibited MKP5 by binding to an allosteric site on the phosphatase but that did not affect the…
Many plans are in preparation to land robotic missions on the surface of the Moon, which will pave the way to return humans to the…
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
The giant planets of the Solar System formed on initially compact orbits, which transitioned to the current wider configuration by means of an orbital instability.…
Oil and water can only be mixed by dispersing droplets of one fluid in the other. When two droplets approach one another, the thin film…
Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood.…
Ability may be widespread in animal kingdom
Much is being made about the erosion of public trust in science. Surveys show a modest decline in the United States from a very high…
The radical new machine might be built faster and cost less than an equivalent conventional atom smasher, boosters say
Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found…
Recent advances on human dendritic cells have opened new avenues to address their subset-specific and cross-lineage programs in cancer.
