Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis

The effect of the timing of norepinephrine initiation on clinical outcomes in patients with septic shock is uncertain. A systematic review and meta-analysis was performed to evaluate the impact of early and late start of norepinephrine support on clinical outcomes in patients with septic shock. We searched the PubMed, Cochrane, and Embase databases for randomized controlled trials (RCTs) and…