Introducing a new kind of technology for the NHS: Alcidion’s Miya Precision platform | Digital Health

A new type of technology is being launched into the NHS that will re-energise the health tech landscape. Miya Precision – the very first smart clinical asset for the NHS – is already attracting the attention of healthcare organisations looking to accelerate their digital adoption. Whether they are pursuing an electronic patient record, best of …

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

The human brain contains trillions of synapses within a vast network of neurons. Synapse remodeling is essential to ensure the efficient reception and integration of external stimuli and to store and retrieve information. Building and remodeling of synapses occurs throughout life under the control of synaptic organizer proteins. Errors in this process can lead to neuropsychiatric or neurological…

Baer’s pochard duck at risk of extinction

The Baer’s pochard ( Aythya baeri ), a migratory duck, used to be widespread in northeast China and eastern Russia, where it would breed, and in central and southeast Asia, where it would migrate for the winter ([ 1 ][1]). However, in recent years, the Baer’s pochard population has decreased to between 150 and 700 Critically Endangered individuals ([ 2 ][2], [ 3 ][3]). China, as the primary…

Neural mechanisms resolving exploitation-exploration dilemmas in the medial prefrontal cortex

Successful behavior in an uncertain, changing, and open-ended environment critically relies on the ability to decide between continuing with the ongoing strategy or exploring new options. Neuroimaging studies have shown that the human medial prefrontal cortex (mPFC) is the part of the brain that primarily deals with this dilemma. However, the contribution of the different mPFC regions remains…

Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE -ε4 in middle-age cognitively unimpaired individuals from the ALFA study

Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. However, it remains to be elucidated whether there is an impact of BDNF Val66Met polymorphism on the…

An allosteric site on MKP5 reveals a strategy for small-molecule inhibition

The MAPK family of kinases regulates diverse physiological and pathophysiological processes and is inactivated by MAPK phosphatases including MKP5. Blocking MKP5 activity has emerged as a potential treatment for dystrophic muscle disease. Gannam et al . identified and characterized a small molecule that inhibited MKP5 by binding to an allosteric site on the phosphatase but that did not affect the…