Bezafibrate after UDCA improves survival in PBC

Patients with primary biliary cholangitis who received bezafibrate after incomplete response to Ocaliva showed lower risk for death or liver transplant, according to a presenter at the Digital International Liver Congress.“Ursodeoxycholic acid [Ocaliva, Intercept] is a first-line treatment for primary biliary cholangitis. As you know, 20% to 30% of patients exhibit incomplete response to

L-carnitine trends toward QOL, cognitive improvement in hepatic encephalitis

Though absolute differences did not emerge in the treatment of hepatic encephalopathy with L-carnitine, a presenter at the Digital International Liver Congress suggested the changes seen indicate more research with higher doses may be warranted.“Twenty-four weeks of L-carnitine supplementation in covert hepatic encephalopathy patients did not improve quality of life,” Eileen Yoon, MD,

Making Anti-Racism A Core Value In Academic Medicine | Health Affairs

Racism, and not race, is a social determinant of health, as leadership from the Ohio State University Wexner Medical Center and Health Sciences Colleges recently declared. Acknowledging this is a foundation for structural and systemic change. Indeed, academic medical centers and health care organizations not acting to eliminate racism are perpetuating its proliferation. Within and outside…

Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials

Guidelines recommend colonoscopy evaluation within 24 hours of presentation or admission in patients with high-risk or severe acute lower gastrointestinal bleeding (LGIB). Meta-analyses of the timing of colonoscopy have relied primarily on observational studies that had major potential for bias. We performed a systematic review of randomized trials to determine optimal timing of colonoscopy for…

Proposal for the return to routine endoscopy during the COVID-19 pandemic

In response to the coronavirus disease 2019 (COVID-19) pandemic, many jurisdictions and gastroenterological societies around the world have suspended nonurgent endoscopy. Subject to country-specific variability, it is projected that with current mitigation measures in place, the peak incidence of active COVID-19 infections may be delayed by over 6 months. Although this aims to prevent the…

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives

Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years. DNA double-strand breaks (DSB) bear the greatest risk of provoking genomic instability, and DNA damage repair (DDR) pathways are crucial in preserving genomic integrity following a plethora of damage…