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The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment
Age-related macular degeneration (AMD) is a progressive retinal disease and the major cause of irreversible vision loss in the elderly. Numerous studies have found both…
Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies.
Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is unclear Therefore, patients with TMA and…
Financial Toxicity in Radiation Oncology: Impact for Our Patients and for Practicing Radiation Oncologists – ClinicalKey
There was an error loading this content. Please refresh the page to try again, or contact us if you continue to experience problems. AbstractWith rising…
Orismilast in moderate-to-severe psoriasis: Efficacy and safety from a 16-week, randomized, double-blinded, placebo-controlled, dose-finding, and phase 2b trial (IASOS) – ClinicalKey
There was an error loading this content. Please refresh the page to try again, or contact us if you continue to experience problems. BackgroundOrismilast is…
Discriminatory healthcare experiences and medical mistrust in patients with serious illness – ClinicalKey
Find ” in this , , or AbstractContextThough discrimination in healthcare settings is increasingly recognized, the discriminatory experiences of patients with serious illness has not…
Cytomegalovirus infection in heart transplant recipients: epidemiology, risk factors, and long-term outcomes from a major transplant center in the United States – ClinicalKey
There was an error loading this content. Please refresh the page to try again, or contact us if you continue to experience problems. Abstract BackgroundDespite…
Early Observations on Effects of Mavacamten on Left Atrial Function in Obstructive Hypertrophic Cardiomyopathy Patients – ClinicalKey
Find ” in this , , or Mavacamten is a myosin ATPase inhibitor that leads to symptomatic improvement and reduction of left ventricular (LV) dynamic…
Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins – PubMed
Effective inhibition of the complement system is needed to prevent the accelerated clearance of nanomaterials by complement cascade and inflammatory responses. Here we show that…
Modeling complement activation on human glomerular microvascular endothelial cells
Atypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage…
Defective C3d caused by C3 p.W1034R in inherited atypical hemolytic uremic syndrome – PubMed
C3 p.W1034R results in an inherited form of aHUS that often presents with recurrent episodes, possibly because of impaired interactions between the C3d and C-terminal…