The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between up or down conformations. Mutations engineered into the spike ectodomain either lock the RBD in the down state or make it adopt the up conformation more readily.
This review focuses on three major aspects of oncoviruses’ role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause…
Nature Microbiology – IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3…
Nature Communications – HIV exposed but uninfected infants may face an increased risk of serious infection and mortality. In this work, the authors utilise a…
Abstract. It has been proposed that coronavirus nsp15 mediates evasion of host cell double-stranded (ds) RNA sensors via its uracil-specific endoribonuclea
C-type lectin receptors (CLRs) comprise a vast family of proteins, several of which play key roles in the immune system. In this article, Reis e…
Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic…
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into…
Nature Immunology – Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans.…
HIV-1 entry into CD4+ T lymphocytes relies on the viral and cellular membranes’ fusion, leading to viral capsid delivery in the target cell cytoplasm. Atg8/LC3B…
