Desmoglein 1 Deficiency Causes Lethal Skin Blistering

Pemphigus is an autoimmune bullous disorder affecting both mucous membranes and the epidermis (Kasperkiewicz et al., 2017). It is widely accepted that pemphigus is caused by autoantibodies primarily targeting desmosomal cadherins desmoglein (Dsg)1 and 3, which are crucial for intercellular cohesion of keratinocytes. The relevance of autoantibodies against other antigens detectable in pemphigus…

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