Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE -ε4 in middle-age cognitively unimpaired individuals from the ALFA study
Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. However, it remains to be elucidated whether there is an impact of BDNF Val66Met polymorphism on the…
