Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration

Bacterial dysbiosis in the gut, particularly an increase in Fusobacterium nucleatum , is associated with colorectal cancer (CRC). Casasanta et al. found that CRC cell–resident F. nucleatum promotes proinflammatory cytokine secretion that stimulates tumor cell migration and invasion. Gene deletion revealed that F. nucleatum infection of HCT116 CRC cells required a membrane adhesin protein that did…