Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

Alterations in the gut microbiota may contribute to autoimmunity through bacterial-mediated immune dysregulation. Tryptophan, an essential amino acid, is critically involved in kynurenine biosynthesis. High kynurenine concentrations have been observed in patients with systemic lupus erythematosus and in lupus-prone mice. Choi et al . now demonstrate that gut bacterial dysbiosis found in…