Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Dysregulated human gut B and T lymphocytes contribute to the immunopathogenesis of ulcerative colitis (UC), a type of inflammatory bowel disease (IBD) characterized by mucosal damage in the colon. Boland et al . probed the immunologic perturbations associated with active UC by sequencing mRNA and clonal antigen receptors from individual CD45+ cells isolated from rectal biopsies or blood of…
