A SARS-CoV-2 hACE2 transgenic mouse infection model recapitulates a number of infection symptoms and pathology in COVID-19 patients. Pre-exposure to SARS-CoV-2 was able to protect mice from severe pneumonia.
Condensate-forming dual-action TFs are identified that reduce high expression but increase low expression of target genes to achieve stable intermediate levels, which is critical for…
The occupancy of ubiquitylation sites is very low and inherently constrained by the amount of ubiquitin molecules, resulting in an ubiquitylation system that operates with…
An inhibitory ligand acts directly on CD3e to regulate T cell activation, and disruption of the interaction boosts tumor-specific T cell cytotoxicity to limit tumor growth.
Pyroptosis is a form of signaling-induced cell death characterized by plasma membrane rupture. This study suggests a “cookie cutter”-like mechanism for pyroptotic cell lysis in…
Integrated structural analyses captured a total of eleven assembly states of bluetongue virus (BTV), revealing insights into the mysterious RNA packaging and capsid assembly of…
Prime editing exhibits strong, chromatin-related position effects and is promoted by active transcriptional elongation. Leveraging these features via epigenetic conditioning of a locus modulates prime…
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when the glycolytic metabolite methylglyoxal transiently disables BRCA2 function. Metabolic…
Dr. Elliott Kieff passed away on January 4, 2024, at the age of 80. The world lost a brilliant scientist and a generous, kind soul.…
In November 2023, Japan’s Ministry of Health, Labour and Welfare granted regulatory approval of ARCT-154, a self-amplifying RNA COVID-19 vaccine developed by Arcturus Therapeutics. Clinical…
“Helicopter research” refers to a practice where researchers from wealthier countries conduct studies in lower-income countries with little involvement of local researchers or community members.…
