Few studies have measured the robustness to perturbations of the final position of a long-range migrating cell. In the nematode Caenorhabditis elegans, the QR neuroblast migrates anteriorly in the young larva, while undergoing three rounds of division. The daughters of QR.pa stop their migration at an anterior body position and acquire a neuronal fate. Previous studies showed that the migration…
Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor (SNARE) proteins catalyze the fusion process of vesicles with target membranes in eukaryotic cells. To do this, they assemble…
ATP-grasp superfamily enzymes contain a hand-like ATP-binding fold and catalyze a variety of reactions using a similar catalytic mechanism. More than 30 protein families are…
Disease-causing missense mutations that occur within structurally and functionally unannotated protein regions can guide researchers to new mechanisms of protein regulation and dysfunction. Here, we…
Pathogenic Escherichia coli (E. coli) causes serious illnesses in human aided by several multiple antibiotic resistance regulator (MarR) transcription factors. Among these proteins, HosA provides…
Novel time-resolved terbium luminescence assays were developed for CDK5 and CDK2 by designing synthetic substrates which incorporate phospho-inducible terbium sensitizing motifs with kinase substrate consensus…
Chlamydia trachomatis, a leading cause of bacteria sexually transmitted infections, creates a specialized intracellular replicative niche by translocation and insertion of a diverse array of…
The protozoan parasite Plasmodium falciparum, which is responsible for the deadliest form of human malaria, accounts for over half a million deaths a year. These…
As part of ongoing epidemiological surveillance for infectious bursal disease virus (IBDV), the hypervariable region (HVR) of the VP2 capsid gene encoded by segment A,…
While traditionally studied for their pro-apoptotic functions, recent research suggests BH3-only proteins also have non-apoptotic roles. Here, we find that EGL-1, the BH3-only protein in…
A critical goal of vision is to detect changes in light intensity, even when these changes are blurred by the spatial resolution of the eye…
