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Mashup Score: 9Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused? - PubMed - 2 hour(s) ago
The use of surrogate outcomes should be limited to situations where a surrogate has demonstrated robust ability to predict meaningful benefits, or where cases are dire, rare or with few treatment options. In both cases, surrogates must be used only when continuing studies examining hard endpoints ha …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Treatment Response Biomarkers: Working Toward Personalized Radiotherapy for Lung Cancer - PubMed - 3 hour(s) ago
Owing to major advances in the field of radiation oncology, patients with lung cancer can now receive technically individualized radiotherapy treatments. Nevertheless, in the era of precision oncology, radiotherapy-based treatment selection needs to be improved as many patients do not benefit or are …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists1Tweet-
RT @radioncoluis: Treatment Response Biomarkers: Working Toward Personalized Radiotherapy for Lung Cancer. https://t.co/jogfqZZUl2 https:/…
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Mashup Score: 1Sarcopenia and Cardiovascular Diseases - PubMed - 1 day(s) ago
Sarcopenia is the loss of muscle strength, mass, and function, which is often exacerbated by chronic comorbidities including cardiovascular diseases, chronic kidney disease, and cancer. Sarcopenia is associated with faster progression of cardiovascular diseases and higher risk of mortality, falls, a …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, CardiologistsTweet-
🥸 2️⃣4️⃣ Chronic inflammation and cellular senescence are key biological processes driving frailty through increased catabolism and sarcopenia. 😱 Yes 👇👇👇 https://t.co/qHYLbqog3L
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Mashup Score: 41Safety and Efficacy of Standard of Care Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma - PubMed - 1 day(s) ago
Ciltacabtagene autoleucel (cilta-cel) CAR-T therapy was approved in 2022 for patients with relapsed/refractory multiple myeloma (RRMM). We report outcomes with cilta-cel in the standard-of-care setting. Patients with RRMM who underwent leukapheresis for cilta-cel manufacturing between 3/1/2022-12/31 …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
#Myeloma Paper of the Day: Study of safety & efficacy of Cilta-cel for RR myeloma finds median PFS not reached (12-month estimate 68%); high ferritin, high-risk cytogenetics & EMD associated w/ inferior PFS; signal for prior BCMA-TT; SPMs in 5.5%: https://t.co/LbslhWBbjM. #mmsm https://t.co/gYEw3nGW1N
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Mashup Score: 18Gabapentinoids and Risk for Severe Exacerbation in Chronic Obstructive Pulmonary Disease : A Population-Based Cohort Study - PubMed - 1 day(s) ago
Canadian Institutes of Health Research and Canadian Lung Association.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Oncologists1Tweet-
RT @Existential_Doc: Gabapentin increases risk of severe COPD exacerbations https://t.co/JMNt6E32qV.
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Mashup Score: 3Nonrandom cell-cycle timing of a somatic chromosomal translocation: The t(X;17) of alveolar soft-part sarcoma occurs in G2 - PubMed - 2 day(s) ago
The cell-cycle timing of somatic chromosomal translocations in cancer remains poorly understood but may be relevant to their etiology and the mechanism of their formation. Alveolar soft-part sarcoma (ASPS) is a rare malignant soft-tissue tumor of uncertain lineage that provides an opportunity to add …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
@srviswanathan @CellCellPress @DanaFarberNews Congratulations ! A fascinating translocation that we explored almost 20 years ago: https://t.co/cIu6dKehHx
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Mashup Score: 5Real-world experience with circulating tumor DNA in cerebrospinal fluid from patients with central nervous system tumors - PubMed - 2 day(s) ago
The characterization of genetic alterations in tumor samples has become standard practice for many human cancers to achieve more precise disease classification and guide the selection of targeted therapies. Cerebrospinal fluid (CSF) can serve as a source of tumor DNA in patients with central nervous …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
Real-world experience with cell-free tumor DNA in cerebrospinal fluid from patients with central nervous system t… https://t.co/jE5xuhuHBU
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Mashup Score: 101Dietary fibre in hypertension and cardiovascular disease management: systematic review and meta-analyses - PubMed - 2 day(s) ago
These findings emphasise the likely benefits of promoting greater dietary fibre intakes for patients with CVD and hypertension. Further trials and cohort analyses in this area would increase confidence in these results.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, General HCPsTweet-
Increasing fiber intake by 5 grams/day led to a reduction in systolic blood pressure by 2.8 mm Hg and diastolic blood pressure by 2.1 mm Hg. This suggests a dose-response relationship where more fiber intake correlates w/ greater reduction in BP. https://t.co/8dJtquHXP6 https://t.co/WQGIDCnafU
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Mashup Score: 6
Among patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, finerenone therapy improved cardiovascular outcomes as compared with placebo. (Funded by Bayer; FIGARO-DKD ClinicalTrials.gov number, NCT02545049.).
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, CardiologistsTweet-
@CardioNerdsJC Note there were relatively few renal events in this HF pop - look back at the baseline Cr (mean of 1.1 mg/dL) This is a different population than the earlier diabetic kidney disease trials with finerenone FIGARO: https://t.co/S33sZNPQZi FIDELIO: https://t.co/8GOFMMmlwn #cardsJC
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Mashup Score: 0Teleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial - PubMed - 3 day(s) ago
NCT04258722 IMPACT: Whereas telemedicine-supported neonatal resuscitation may improve the quality of resuscitation within hospital settings, unique challenges include the need for real-time, high-fidelity audio-video communication with a low failure rate. The no-flow fraction, which evaluates the qu …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, PediatricsTweet-
Teleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial https://t.co/yMGek8ysgV
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https://t.co/7D5DddiKPK