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Mashup Score: 0Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label | Annals of Internal Medicine - 17 hour(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? View all available purchase options and get full access to this article. Walsh BS, Sarpatwari A, Rome BN, et al. Frequency of first generic drug approvals with “skinny labels” in the United States. JAMA Intern Med. 2021;181:995-997. [PMID: 33779681] doi: 10.1001/jamainternmed.2021.0484 Walsh BS, Kesselheim AS, Sarpatwari
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Mashup Score: 2
Background: Many patients participate in cancer trials to access new therapies. The extent to which new treatments produce clinical benefit for trial participants is unclear. Purpose: To estimate the progression-free survival (PFS) and overall survival (OS) advantage of assignment to experimental groups in randomized trials for 6 solid tumors. Data Sources: ClinicalTrials.gov was searched for trials of investigational drugs with results posted between 2017 and 2021. Study Selection: Investigational drugs were defined as those not yet having full approval from the U.S. Food and Drug Administration for the study indication. Trials were included if they were randomized and tested drugs or biologics. Data Extraction: Data extraction was completed by 2 independent reviewers. Data were pooled using a random-effects model. Data Synthesis: The sample included 128 trials comprising 141 comparisons of a new drug and a comparator. These comparisons included 47 050 patients. The pooled hazard rati
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Mashup Score: 455The Effect of Open-Label Semaglutide on Metabolic Dysfunction–Associated Steatotic Liver Disease in People With HIV | Annals of Internal Medicine - 19 hour(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? View all available purchase options and get full access to this article. Marso SP, Bain SC, Consoli A, et al; SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375:1834-1844. [PMID: 27633186] doi: 10.1056/NEJMoa1607141 Newsome PN, Buchholtz K, Cusi K, et
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Mashup Score: 6Annals of Internal Medicine: Latest - 2 day(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? Laurence Duquenne, MD, Elizabeth M. Hensor, PhD, Michelle Wilson, MSc, Leticia Garcia-Montoya, MD, Jacqueline L. Nam, MBBCh, FCP (SA), Cert Rheum (SA), PhD, Jianhua Wu, PhD, Kate Harnden, MBChB, Innocent Chidi Anioke, MSc, Andrea Di Matteo, PhD, Rahaymin Chowdhury, MBChD, MD, Navkiran Sidhu, MD, Frederique Ponchel, PhD,
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Mashup Score: 455
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? View all available purchase options and get full access to this article. Marso SP, Bain SC, Consoli A, et al; SUSTAIN-6 Investigators. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375:1834-1844. [PMID: 27633186] doi: 10.1056/NEJMoa1607141 Newsome PN, Buchholtz K, Cusi K, et
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Mashup Score: 2
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? Background: Firearm injuries—fatal and nonfatal—disproportionately affect younger Americans, have increased in recent years (1, 2), and are the leading cause of death among children and adolescents (3). The 4-item (fighting; friend weapon carrying; hearing gunshots in one’s neighborhood; received firearm threats), 10-point
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Mashup Score: 2Low-Value Care: A Multilayer Problem Requiring Multilayer Solutions | Annals of Internal Medicine - 2 day(s) ago
In their article, Dindinger-Hill and colleagues study what happens to physician use of 2 low-value services, prostate-specific antigen testing and mammography in Medicare beneficiaries aged 75 year…
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Mashup Score: 1CME by Topic - 3 day(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? Annals of Internal Medicine and Annals of Internal Medicine: Clinical Cases offer convenient ways to fulfill both your CME and MOC requirements. After logging in, it takes just a few minutes to earn credit using one of two models: complete the short quiz that accompanies articles with the “CME/MOC” label or document how an
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Mashup Score: 1Annals of Internal Medicine - 4 day(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? The Pirates Ann I ntern Med. 1999;131(6):472-473. doi:10.7326/0003-4819-131-6-199909210-00015
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Mashup Score: 4Comparison of Hospital Mortality and Readmission Rates by Physician and Patient Sex | Annals of Internal Medicine - 5 day(s) ago
Background: Little is known as to whether the effects of physician sex on patients’ clinical outcomes vary by patient sex. Objective: To examine whether the association between physician sex and hospital outcomes varied between female and male patients hospitalized with medical conditions. Design: Retrospective observational study. Setting: Medicare claims data. Patients: 20% random sample of Medicare fee-for-service beneficiaries hospitalized with medical conditions during 2016 to 2019 and treated by hospitalists. Measurements: The primary outcomes were patients’ 30-day mortality and readmission rates, adjusted for patient and physician characteristics and hospital-level averages of exposures (effectively comparing physicians within the same hospital). Results: Of 458 108 female and 318 819 male patients, 142 465 (31.1%) and 97 500 (30.6%) were treated by female physicians, respectively. Both female and male patients had a lower patient mortality when treated by female physicians; how
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