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Mashup Score: 4Biology of Precancers and Opportunities for Cancer Interception: Lesson from Colorectal Cancer Susceptibility Syndromes - 8 month(s) ago
Abstract. Hereditary gastrointestinal cancer is associated with molecular and neoplastic precursors which have revealed much about sporadic carcinogenesis. Therefore, an appreciation of constitutional and somatic events linked to these syndromes have provided a useful model for the development of risk models and preventative strategies. In this review, we focus of two of the best characterized syndromes, Lynch syndrome (LS) and familial adenomatous polyposis (FAP). Our understanding of the neoplasia-immune interaction in LS has contributed to the development of immune mediated therapies including cancer preventing vaccines and immunotherapy for cancer precursors. Chemoprevention in LS with aspirin and nonsteroidal anti-inflammatory drugs has also translated into clinical cancer, however the efficacy of such agents in FAP remains elusive when cancer is applied as an endpoint in trials rather than the use of ‘indirect’ endpoints such as polyp burden, and requires further elucidation of b
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Biology of Precancers and Opportunities for Cancer Interception: Lesson from Colorectal Cancer Susceptibility Syndromes - 9 month(s) ago
Abstract. Hereditary gastrointestinal cancer is associated with molecular and neoplastic precursors which have revealed much about sporadic carcinogenesis. Therefore, an appreciation of constitutional and somatic events linked to these syndromes have provided a useful model for the development of risk models and preventative strategies. In this review, we focus of two of the best characterized syndromes, Lynch syndrome (LS) and familial adenomatous polyposis (FAP). Our understanding of the neoplasia-immune interaction in LS has contributed to the development of immune mediated therapies including cancer preventing vaccines and immunotherapy for cancer precursors. Chemoprevention in LS with aspirin and nonsteroidal anti-inflammatory drugs has also translated into clinical cancer, however the efficacy of such agents in FAP remains elusive when cancer is applied as an endpoint in trials rather than the use of ‘indirect’ endpoints such as polyp burden, and requires further elucidation of b
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Christine Ko re-joins Jonathan Sackier to discuss cognitive bias, carcinogenesis, and visual perception in dermatology and dermatopathology.
Source: European Medical JournalCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0Menstrual Factors, Reproductive History and Liver Cancer Risk: Findings from a Prospective Cohort Study in Chinese Women - 1 year(s) ago
AbstractBackground:. Many studies suggested that menstrual and reproductive factors affected the gender disparity in liver carcinogenesis, but the results were inconsistent. Moreover, there are few studies in Asian populations. Therefore, our study was to explore the association of menstrual and reproductive factors on liver cancer risk in Chinese women.Methods:. 72,807 women were recruited in…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Menstrual Factors, Reproductive History and Liver Cancer Risk: Findings from a Prospective Cohort Study in Chinese Women - 1 year(s) ago
AbstractBackground:. Many studies suggested that menstrual and reproductive factors affected the gender disparity in liver carcinogenesis, but the results were inconsistent. Moreover, there are few studies in Asian populations. Therefore, our study was to explore the association of menstrual and reproductive factors on liver cancer risk in Chinese women.Methods:. 72,807 women were recruited in…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Nutrients and Exercise Affect Tumor Development - 2 year(s) ago
At a recent conference, researchers reviewed the data on the effects of diet and exercise on cancer. These factors have different effects at different phases of carcinogenesis.
Source: MedscapeCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Conferences | Keystone Symposia - 2 year(s) ago
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Source: www.keystonesymposia.orgCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Viral and cellular oncogenes promote immune evasion - Oncogene - 2 year(s) ago
Thirteen percent of cancers worldwide are associated with viral infections. While many human oncogenic viruses are widely endemic, very few infected individuals develop cancer. This raises the question why oncogenic viruses encode viral oncogenes if they can replicate and spread between human hosts without causing cancer. Interestingly, viral infection triggers innate immune signaling pathways…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Plenarsprecher - 3 year(s) ago
31. Deutscher Hautkrebskongress 8.–11. September 2021 • Hybrid
Source: www.ado-kongress.deCategories: Future of Medicine, Latest HeadlinesTweet-
Honored to give today plenary lecture at the 31st German Skin Cancer Virtual Congress #ADO2021. I will explain how DNA methylation contributes to #multistage #skin #carcinogenesis and how can also predict response to anti-PD-1 #immunotherapy in #melanoma https://t.co/rQw6SX9Tm8 https://t.co/EjDgYfwF8i
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Mashup Score: 3Mitochondrial DNA variation and cancer - Nature Reviews Cancer - 3 year(s) ago
Variation in mitochondrial DNA (mtDNA) is common in certain tumours. This Review discusses the relevance of heritable, somatic and ancient mtDNA variants to cancer and how subtle changes in mtDNA result in metabolic, epigenetic and transcriptional changes that affect carcinogenesis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
#ICYMI— @kevinjmonahan reviews #precancer biology & preventive strategies of #LynchSyndrome & familial adenomatous polyposis. Lessons from those hereditary GI syndromes could reveal sporadic #carcinogenesis & aid precision prevention. https://t.co/r0z1uHaZhQ @StMarksGenomics https://t.co/aSWmVZ9G9Z