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Mashup Score: 0Gastrointestinal Cancers Global Burden - 4 year(s) ago
Christian Abnet and Katherine McGlynn in the Metabolic Epidemiology Branch (MEB), in collaboration with the International Agency for Research on Cancer, examined the global burden of the five major types of gastrointestinal cancer, which include those of the stomach, liver, esophagus, pancreas, and colorectum.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1GWAS Identifies Risk Loci for Breast Cancer Subtypes - 4 year(s) ago
Montserrat Garcia-Closas and colleagues report findings from a new genome-wide association study (GWAS) for breast cancer identifying 32 novel susceptibility loci. Importantly, this study reveals genetic risk for breast cancer subtypes and expands the potential for the development of subtype-specific polygenic risk scores.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
New #breastcancer genetics study in @NatureGenet has identified susceptibility loci that increase our understanding of the genetic architecture of different subtypes and may improve subtype-specific polygenic risk scores. https://t.co/Oib5wvv8zD #NCI_ITEB #DCEGSummerReading https://t.co/tGybNJTF3T
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Mashup Score: 0Higher Step Count Linked with Lower Mortality - 4 year(s) ago
Pedro Saint-Maurice, Charles Matthews, and collaborators find taking more steps daily improves life expectancy.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
Taking more steps per day is associated with longer life expectancy across the population, study finds. https://t.co/qemmIDZuRR @psaintmaurice @JAMA_current #NCI_MetabolicEpi #DCEGSummerReading https://t.co/EE9JB9Oilb
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Mashup Score: 0Metformin May Reduce Cancer Risk in Myotonic Dystrophy - 4 year(s) ago
Type 2 diabetes is prevalent among patients with myotonic dystrophy type 1 (DM1) and was found to be associated with increased cancer risk. Metformin use in those patients may reduce this excess cancer risk. A larger study is needed to validate or refute these findings.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
Study finds risk of cancer in #MyotonicDystrophy Type 1 patients with #Type2Diabetes may be reduced by the use of #metformin https://t.co/rQ5I4CKa0k #NCI_ClinicalGenetics #DCEGSummerReading https://t.co/xvq46POW1x
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Mashup Score: 0Decline in U.S. Hepatocellular Carcinoma Rates - 4 year(s) ago
Hepatocellular carcinoma (HCC) incidence rates plateaued in 2013 and declined in 2016, particularly among men, adults 50-64 years old, Hispanics, and Asian Pacific Islanders in the U.S.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
Study in @AGA_Gastro finds overall incidence rates of hepatocellular carcinoma in the U.S. declined in 2016, particularly among men, adults 50-64 years old, Hispanics, and Asian Pacific Islanders. @meredithshiels https://t.co/GBlOxzbwYY #NCI_InfectionsImmunoEpi #DCEGSummerReading https://t.co/YpiJsjdXYZ
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Mashup Score: 0APOBEC3-Induced Mutations in HPV 16 Viral Clearance - 4 year(s) ago
Bin Zhu and Lisa Mirabello conducted the largest HPV 16 whole-genome sequencing study to evaluate the contribution of genetic variation in HPV16 to infection outcome. They found APOBEC3-induced mutations associated with benign cervical infections.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
Study in @NatureComms finds cervical infections of #HPV16 with APOBEC3-induced mutations were less likely to progress to #cervicalcancer. #HPV @LisaMirabello_ https://t.co/XULQpJgqMw #NCI_ClinicalGenetics #DCEGSummerReading https://t.co/zMVUAZ0qoy
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Mashup Score: 2HLA-DPB1 Variants May Increase Risk of Severe Aplastic Anemia - 4 year(s) ago
Shahinaz Gadalla and Sharon Savage identify genetic variants in HLA-DPB1 associated with increased risk of severe aplastic anemia that may offer etiologic insights, according to findings in The American Journal of Human Genetics on February 6, 2020.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
Genetic variants in HLA-DPB1 are associated with increased risk of severe #AplasticAnemia and may offer insight into the genetic causes of this #raredisease, study finds. https://t.co/YfXFIAJxDo @SharonSavageMD @AJHGNews #NCI_ClinicalGenetics #DCEGSummerReading https://t.co/FaFsjPySTW
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Mashup Score: 1
Lisa Mirabello and Sharon Savage in the Clinical Genetics Branch searched for potential harmful variants in 238 known cancer-susceptibility genes in people with osteosarcoma and found that 28% of patients with osteosarcoma carry a likely harmful variant in a cancer-susceptibility gene.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
Study in @JAMAOnc led by @LisaMirabello_ provides fascinating insight into #genetics of #Osteosarcoma-most common cancerous #BoneTumor of kids/adolescents. https://t.co/ZZi9ogTAST #NCI_ClinicalGenetics #DCEGSummerReading https://t.co/TB5AEGd0Sp
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Mashup Score: 1Genetic Study on African Ancestry in the Americas - 4 year(s) ago
Meredith Yeager, in the Cancer Genomics Research Laboratory, conducted a genetic study to determine how different African groups contributed to the genetic structure of Caribbean, as well as, North, Central, and South American populations.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
#Population #genetics study in @OfficialSMBE determined how different African groups contributed to the genetic structure of American populations; found geographical & geopolitical factors influenced genetic distribution. @MeredithYeager https://t.co/26tD2j6nSq #DCEGSummerReading https://t.co/droXcDpfSn
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Mashup Score: 0GWAS Meta-Analysis on Cutaneous Melanoma - 4 year(s) ago
A new study identified 85 genomic loci associated with cutaneous melanoma risk using an integrative approach based on genome-wide association studies and transcriptome association approaches. These findings were published in Nature Genetics on April 27, 2020.
Source: National Cancer InstituteCategories: Genetics, Latest HeadlinesTweet-
A new study in @NatureGenet identified 85 genomic loci associated with cutaneous #melanoma risk using an integrative approach based on genome-wide association studies. https://t.co/1dU92k3S4I #NCI_ITEB #NCI_TranslationalGenomics #DCEGSummerReading https://t.co/Ckd4KYpXUs
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Study in @AGA_Gastro describes global trends in estimated rates of five GI cancers (stomach, esophageal, pancreatic, liver & colorectal). #CancerPrevention strategies may help reduce global burden. https://t.co/1cQUE09Dur @IARCWHO #NCI_MetabolicEpi #DCEGSummerReading https://t.co/RBgGiaRDLP