• Mashup Score: 5

    Tarini Shankar Ghosh and Ana Maria Valdes evaluate the evidence for clinical effects of microbiome altering interventions on cardiometabolic traits ### Key messages Cardiometabolic diseases are one of the main causes of morbidity and mortality in western countries and are increasing in low and middle income countries.1 Dietary intake is one of the main determinants of cardiometabolic health1 and of microbiome composition.2 The gut microbiome is known to play an important part in the development of cardiometabolic diseases, including hypertension, diabetes, and obesity.2 This is thought to be linked with the ability of the gut microbiome to modulate inflammation, insulin sensitivity, and blood lipid levels, and is hypothesised to be mediated by specific microbially produced metabolites such as short chain fatty acids (SCFAs), secondary bile acids, phenylacetylglutamine, and trimethylamine-N-oxide.2 As well as their direct influence, gut microbes can also modulate the response of the hum

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    • 📢 While we know microbial metabolites matter for health, @tarini_ghosh @NottmBRCMSIR say we're still in the early stages of understanding how to manipulate the #gutmicrobiome in order to influence #disease outcomes. #science #research 👉Learn more: https://t.co/Byi3o1eh8A

  • Mashup Score: 6

    Objective Polymorphisms in the antifungal signalling molecule CARD9 are associated with ankylosing spondylitis (AS). Here, we investigated the cellular mechanism by which CARD9 controls pathogenic Th17 responses and the onset of disease in both experimental murine AS and patients. Methods Experiments in SKG, Card9−/−SKG, neutrophil-deplete SKG mice along with in vitro murine, neutrophil and CD4+ T cell cocultures examined Card9 function in neutrophil activation, Th17 induction and arthritis in experimental AS. In AS patients the neutrophil: Bath Ankylosing Spondylitis Functional Index relationship was analysed. In vitro studies with autologous neutrophil: T cell cocultures examined endogenous CARD9 versus the AS-associated variant (rs4075515) of CARD9 in T cellular production of IL-17A. Results Card9 functioned downstream of Dectin-1 and was essential for induction of Th17 cells, arthritis and spondylitis in SKG mice. Card9 expression within T cells was dispensable for arthritis onset

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    • Study identifies biomarker that could lead to better treatment for autoimmune #disease https://t.co/xLMsG2YNdq https://t.co/NqggaRy5ue

  • Mashup Score: 0
    PNAS Nexus - 6 month(s) ago

    PNAS Nexus is a broad, highly selective, open access journal with a focus on innovation and rapid publication. It publishes innovative and interdisciplinary research and perspectives from across the biological, physical, and social sciences.

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    • The eighth issue of volume two of @PNASNexus is complete! Discover insights into the #lifespans of humans and great apes, host adaptation in vector-borne #disease systems, the water #permeability of human skin, and more. Read now: https://t.co/3eQtVdDUoP https://t.co/fUjQehjjDU