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    Food allergy is a common, chronic disease that is burdensome for patients and families, with multiple dietary and social limitations and a significant psychological impact stemming from the fear of accidental exposures and potentially severe, life-threatening reactions. Until recently, the only management option consisted of strict food avoidance. Food allergen immunotherapy (food AIT) has emerged as an alternative, active intervention to strict food avoidance, with a multitude of research studies supporting its efficacy and good safety profile.

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    With advances in molecular and computational science, epitope-specific IgE antibody profiling has been developed and recently brought into clinical practice. Epitope-based testing detects IgE antibodies that directly bind to antigenic sites of an allergen, providing increased resolution specificity and fewer false-positive results for diagnosing food allergy. Epitope-binding profiles may also serve as prognostic markers of food allergy and help predict quantities of allergen that would provoke a reaction (ie, eliciting dose, possible severity of a reaction after allergen ingestion, and outcomes of treatment options such as oral immunotherapy [OIT]).

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    An accurate diagnosis of IgE-mediated allergies is necessary to inform risk management for severe allergic reactions including anaphylaxis for food, venom, and drug allergies. The most widely available laboratory test for allergy is serum-specific IgE testing, which is routinely used for food allergy and insect sting allergy. Testing for specific IgE is limited by high sensitivity and low specificity, resulting in concern regarding overdiagnosis. Testing of allergen components has led to improved diagnosis for some food and venom allergens.

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    Incomplete understanding of the multiple mechanisms underlying the link between ultra-processed foods and cardiometabolic health should not be an excuse for inaction argue Mathilde Touvier and colleagues The effect of diet on health has historically been considered from a nutrient based perspective—for example, excess total fat, saturated fat, dietary cholesterol, calories, sugar, or salt and lack of dietary fibre, vitamins, and minerals.1 More recently, this approach has been complemented by extensive evidence supporting health effects of dietary patterns (eg, the Mediterranean diet), characterised by various dietary scores such as the Alternative Healthy Eating Index (AHEI), or DASH (Dietary Approaches to Stop Hypertension) diet.2 However, the degree of processing and formulation of foods was not taken into account. For instance, all vegetable soups were considered similar, regardless of whether they were homemade, industrial canned, or industrial dehydrated and contained food additi

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    • Shortcomings in the evidence base around #ultraprocessed #food and #cardiometabolic health isn't an excuse for inaction. @CRESS_U1153 & co say we know enough to justify #publichealth response to reduce individual consumption. 👉Read more: https://t.co/xxdG2CfoHF @BernardSrour

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    Article courtesy of Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world’s top cardiologists, a best-selling author, lecturer, and a leading expert in plant-based nutrition and holistic care.

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    • RT @WorldHealth_Net: https://t.co/qvpzekjwgh #obesity #weight #weightloss #nuts #almonds #lifestyle #diet #nutrition #food with @drjkahn