• Mashup Score: 0

    Background We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. Methods CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the

    Tweet Tweets with this article
    • A Phase III #clinicaltrial of autologous #CD34+ #cell #transplantation accelerates time to radiological #fracture nonunion repair by 2.8 times. https://t.co/HOZhbSWtyZ Kuroda, Niikura et al. from @KobeU_Global report of interest to @MSKmedBMC #orthotwitter #stemcell https://t.co/9EdmYzRowI

  • Mashup Score: 0

    Muscle mass as measured through high-resolution peripheral quantitative CT may not interact with bone measures to affect the risk for fractures among older men, though more studies are needed, according to study data. β€œIn this prospective study of older men, there were no consistent interactions between bone and muscle on fracture risk when using advancing medical imaging,” Ben Kirk,

    Tweet Tweets with this article
    • #ICYMI: β€œA larger sample size and longer follow-up may have been needed to clarify if there is a multiplicative or additive effect of bone and muscle on #fracture risk.” @DrBenKirk @UniMelbMDHS https://t.co/xnO7alaCDh

  • Mashup Score: 0
    Bone & Joint - 9 month(s) ago

    The British Editorial Society of Bone & Joint Surgery

    Tweet Tweets with this article
    • πŸ“’ JULY EDITOR'S PICKS ROUND-UP πŸŽ‰ Read this month's #BJJ picks from Prof Fares Haddad in the current issue today! #Fracture #Infection #PedsOrtho #GenderEquality #WomenInSurgery @Sdownie04 @Tiny_Ortho_Tom @deboraheastwood https://t.co/EFTf1NPNtc https://t.co/oUV7ksBDGO