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Mashup Score: 0Substitution rate heterogeneity across hexanucleotide contexts in noncoding chloroplast DNA - 11 month(s) ago
Abstract. Substitutions between closely related noncoding chloroplast DNA sequences are studied with respect to the composition of the 3 bases on each side of t
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Identifying strengths and weaknesses of methods for computational network inference from single-cell RNA-seq data - 11 month(s) ago
Abstract. Single-cell RNA-sequencing (scRNA-seq) offers unparalleled insight into the transcriptional programs of different cellular states by measuring the tra
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
McCalla et al. present an extended comparison of recent algorithms of network inference from scRNA-seq datasets and identifies common strengths and weaknesses on different types of gold standards. #G3Journal | https://t.co/HfTP7grG01 https://t.co/MePW03Zi1A
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Mashup Score: 1rate of spontaneous mutations in yeast deficient for MutSβ function - 11 month(s) ago
Abstract. Mutations in simple sequence repeat loci underlie many inherited disorders in humans, and are increasingly recognized as important determinants of nat
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Plavskin et al. perform mutation accumulation in yeast strains with abrogated MutSβ function with the goal to better understand the role of this complex in mismatch repair and the determinants of simple sequence repeat mutation predisposition. #G3Journal | https://t.co/19dihnttlK https://t.co/mS1jUcPopD
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Mashup Score: 4
Abstract. The ability to predict which genes will respond to the perturbation of a transcription factor serves as a benchmark for our systems-level understandin
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Kang et al. take on the challenge of training #MachineLearning models that can predict which genes will respond to the perturbation of a transcription factor perturbations without using any data from perturbed cells. #G3Journal | https://t.co/t0UGaTCP9h https://t.co/l9BUKtwDse
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Mashup Score: 0Integrative analysis and prediction of human R-loop binding proteins - 11 month(s) ago
Abstract. In the past decade, there has been a growing appreciation for R-loop structures as important regulators of the epigenome, telomere maintenance, DNA re
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
R-loop structures are regulators of the epigenome, telomere maintenance, DNA repair, and replication. Here, Kumar et al. extract common protein features and use random forest machine learning classifiers to score R-loop binding potential. #G3Journal | https://t.co/gDZ298YTV3 https://t.co/mPx3hlGhD7
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Mashup Score: 0Function of cell adhesion molecules in differentiation of ray sensory neurons in C. elegans - 11 month(s) ago
Abstract. For proper functioning of the nervous system, it is crucial that neurons find their appropriate partners and build the correct neural connection patte
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Sakai et al. analyze the effects of mutations in cell adhesion molecules genes on the morphology and synapses of sensory neurons in #Celegans by examining their effect on axon trajectory and localization of pre-synaptic components. #G3Journal | https://t.co/U4CoaiFFJ1 https://t.co/S5bJK8J7eR
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Mashup Score: 0Comparative analysis of the testes from wild-type and Alkbh5-knockout mice using single-cell RNA sequencing - 11 month(s) ago
Abstract. The RNA demethylase ALKBH5 is regarded as the “eraser” in N6-methyladenosine modification. ALKBH5 deficiency causes male infertility in mice; however,
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Hong et al. provide the first single-cell RNA sequencing profile of the testes of mice lacking the N6-methyladenosine RNA eraser ALKBH5, highlighting its role in germ cell development and spermatogenesis. #G3Journal | https://t.co/DLD72hjgKI https://t.co/Kpv5UY8Wl4
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Mashup Score: 0
Abstract. Understanding the targets of selection associated with changes in behavioral traits represents an important challenge of current evolutionary research
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Espíndola-Hernández et al. search for signals of accelerated rates of evolution associated with a diurnal lifestyle in owls using a genome-wide comparative approach and identify owl-specific noncoding elements as potential candidates. #G3Journal | https://t.co/qGDvLS1viN https://t.co/jgGb696Z17
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Mashup Score: 0Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation - 11 month(s) ago
Abstract. In the negative feedback loop driving the Neurospora circadian oscillator, the negative element, FREQUENCY (FRQ), inhibits its own expression by promo
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Wang et al. systematically investigate the role in period determination of all 110 reported phosphorylation sites on the circadian clock protein FRQ, and identify clusters determining period length and temperature compensation. #G3Journal | https://t.co/zJ9wYJRWdI https://t.co/EhgEGJZU38
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Mashup Score: 3Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks - 11 month(s) ago
Abstract. Fanconi anemia genes play key roles in metazoan DNA damage responses, and human FA mutations cause numerous disease phenotypes. In human cells, activa
Source: OUP AcademicCategories: Genetics, Latest HeadlinesTweet-
Clay et al. employ several novel and recently developed #Drosophila tools to study conserved roles of fancd2 — a gene associated with the autosomal recessive condition Fanconi anemia in humans — in response to dsDNA breaks. #G3Journal | https://t.co/wd2LqrfMIm https://t.co/0kRNvGiVqo
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Results by Brian Morton demonstrate that noncoding sites in different contexts are evolving along very different evolutionary trajectories and that substitution dynamics are far more complex than typically assumed. #G3Journal | https://t.co/qpO7K1oQac https://t.co/0Sw2YKVQOg