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    Background: Inadequate dose titration and poor adherence to basal insulin can lead to suboptimal glycemic control in persons with type 2 diabetes (T2D). Once-weekly insulin icodec (icodec) is a basal insulin analogue that is in development and is aimed at reducing treatment burden. Objective: To compare the effectiveness and safety of icodec titrated with a dosing guide app (icodec with app) versus once-daily basal insulin analogues (OD analogues) dosed per standard practice. Design: 52-week, randomized, open-label, parallel-group, phase 3a trial with real-world elements. (ClinicalTrials.gov: NCT04760626) Setting: 176 sites in 7 countries. Participants: 1085 insulin-naive adults with T2D. Intervention: Icodec with app or OD analogue (insulin degludec, insulin glargine U100, or insulin glargine U300). Measurements: The primary outcome was change in glycated hemoglobin (HbA1c) level from baseline to week 52. Secondary outcomes included patient-reported outcomes (Treatment Related Impact

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    • A new trial (ONWARDS 5) found that once-weekly insulin #icodec titrated with a dosing guide app demonstrated superior reduction in HbA1c levels and similarly low #hypoglycemia rates compared with once-daily #insulin: https://t.co/ULWSDxDGcY https://t.co/6I1DW9xUBY

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    Background: Inadequate dose titration and poor adherence to basal insulin can lead to suboptimal glycemic control in persons with type 2 diabetes (T2D). Once-weekly insulin icodec (icodec) is a basal insulin analogue that is in development and is aimed at reducing treatment burden. Objective: To compare the effectiveness and safety of icodec titrated with a dosing guide app (icodec with app) versus once-daily basal insulin analogues (OD analogues) dosed per standard practice. Design: 52-week, randomized, open-label, parallel-group, phase 3a trial with real-world elements. (ClinicalTrials.gov: NCT04760626) Setting: 176 sites in 7 countries. Participants: 1085 insulin-naive adults with T2D. Intervention: Icodec with app or OD analogue (insulin degludec, insulin glargine U100, or insulin glargine U300). Measurements: The primary outcome was change in glycated hemoglobin (HbA1c) level from baseline to week 52. Secondary outcomes included patient-reported outcomes (Treatment Related Impact

    Tweet Tweets with this article
    • A new trial (ONWARDS 5) found that once-weekly insulin icodec titrated with a dosing guide app demonstrated superior reduction in HbA1c levels and similarly low #hypoglycemia rates compared with once-daily #insulin: https://t.co/Zw0pgyJDdL https://t.co/nvYmgwjIY5

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    New to DocMatter, or having trouble logging in? Click here to find your account Contact us for other issues, or Request to join.

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    • Join the DocMatter discussion on the case of a woman (37) who developed #hypoglycemia-like symptoms in early 2022 after COVID infection. Symptoms progressed despite a low-carb diet and acarbose, resulting in Cushings-like symptoms: https://t.co/tmAkbH3upT

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    The Endocrine Society and the American College of Osteopathic Family Physicians have collaborated to develop a holistic certificate program that covers the many facets of diabetes care.

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    • We are offering a 10% discount on Comprehensive Care for Persons with Diabetes (https://t.co/7BZhxpZnJJ). Stop by booth #1104 at #ADCES2023 to learn about our #diabetes resources like our latest #hyperglycemia and #hypoglycemia guidelines (https://t.co/hRk2RcApVO) @ADCESdiabetes

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    We are pleased to announce the release of our latest clinical practice guideline: Management of Hyperglycemia in Hospitalized Adult Patients in Non-Critical Care Settings! This new guideline reflects evolving clinical science and provides evidence-based recommendations for clinical care and practice managing hyperglycemia in the inpatient setting.

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    • Come meet with us to learn about our member benefits and receive complimentary copies of our latest #hyperglycemia (https://t.co/6ntsuKwaka) and #hypoglycemia (https://t.co/nN9focZ0vV) clinical practice guidelines at #ADCES2023 booth #1104: https://t.co/hRk2RcApVO @ADCESdiabetes

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    Adults with type 1 diabetes and impaired awareness of hypoglycemia have worse diabetes-related distress than those with normal hypoglycemia awareness, according to a study published in Diabetic Medicine. “Our study highlights the persistent relation between impaired awareness of hypoglycemia and diabetes distress with manifestations across emotions, cognitions and behaviors, despite the use

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    • #ICYMI: "Apparently, widespread use of intermittently scanned #CGM technology has not closed this gap between impaired awareness of hypoglycemia and normal awareness of #hypoglycemia." @DiabeticMed @radboudumc https://t.co/gfdWSMqtzF

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    The FDA approved an allogenic pancreatic islet cellular therapy for adults with type 1 diabetes who struggled to achieve their target HbA1c due to repeated episodes of severe hypoglycemia, according to an agency press release. The novel cell therapy (Lantidra, CellTrans Inc.) is made from deceased donor pancreatic cells and is administered as a single infusion into the patient’s hepatic

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    • #ICYMI: “Today’s approval, the first-ever cell therapy to treat patients with type 1 #diabetes, provides individuals living with type 1 diabetes and recurrent severe #hypoglycemia an additional treatment option." @US_FDA #diabetes #hypoglycemia https://t.co/7ymdxJsIyD