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Mashup Score: 9JCI Insight - Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression - 3 month(s) ago
Animal experiments. C57BL/6J (WT; catalog 000664) mice were purchased from Jackson Laboratory. FXR whole-body KO mice (FXR-KO) and FXR-specific deletion mice (FXRfl/fl) were gifted from Ronald Evans’s lab (Salk Institute). CX3CR1-Cre mice (catalog 025524) were purchased from Jackson Laboratory. All the mice were maintained on a normal chow diet (LabDiet 5001). To induce classic CAC in WT mice, a…
Source: insight.jci.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 8Differential Manifestations of Inflammatory Bowel Disease Based on Race and Immigration Status - 4 month(s) ago
The prevalence of inflammatory bowel disease (IBD) is increasing globally. In this context, identifying risk factors for severe disease is important. …
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet-
#InflammatoryBowelDisease varies by race, sex and birthplace, researchers find @RutgersU https://t.co/6aX1BStZwX https://t.co/u45GPWUjI9
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Mashup Score: 0Strong Satisfaction Levels with Adalimumab Biosimilar Seen Among Initiators, Switchers with IBD - 4 month(s) ago
This new analysis on IBD patients initiating biologic therapy with the biosimilar ABP 501 indicates that the drug’s lower cost and efficacy may lead to greater use.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet-
In new findings, patients with #InflammatoryBowelDisease (IBD) & treating clinicians both acknowledged strong satisfaction ratings of the adalimumab biosimilar ABP 501 among both treatment initiators and switchers. View the summary here: https://t.co/n8aaiXjRnn
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Mashup Score: 0Strong Satisfaction Levels with Adalimumab Biosimilar Seen Among Initiators, Switchers with IBD - 5 month(s) ago
This new analysis on IBD patients initiating biologic therapy with the biosimilar ABP 501 indicates that the drug’s lower cost and efficacy may lead to greater use.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet-
In new findings, patients with #InflammatoryBowelDisease (IBD) & treating clinicians both acknowledged strong satisfaction ratings of the adalimumab biosimilar ABP 501 among both treatment initiators and switchers. View the summary here: https://t.co/n8aaiXjRnn
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Mashup Score: 0Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study - BMC Medicine - 6 month(s) ago
Background The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between IBD and extracolonic cancers. Methods Independent genetic variants strongly associated with IBD were extracted as instrumental variables from genome-wide association study (GWAS) conducted by the International IBD Genetics Consortium including 12,882 IBD patients, 5956 Crohn’s disease (CD) patients, and 6968 ulcerative colitis (UC) patients. Three sources of cancer GWAS were selected as outcome data. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of IBD on 32 extracolonic cancers. The meta-analysis was applied to assess the combined causal effect with multiple MR results. Results IBD, CD, and UC have potential causal associations with oral cavity cancer (IBD: OR = 1.180, 95% CI: 1.059 to 1.316, P = 0.003; CD: OR = 1
Source: bmcmedicine.biomedcentral.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Genetically predicted #InflammatoryBowelDisease suggested to be a risk factor in the development of oral cavity and breast #cancer via #MendelianRandomization Hui Gao et al. publish in #BMCMedicine https://t.co/LseT9HpdTV https://t.co/5Q5rcrhChy
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Mashup Score: 7New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function - 8 month(s) ago
Objectives Interleukin (IL) 17s cytokines are key drivers of inflammation that are functionally dysregulated in several human immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA), psoriasis and inflammatory bowel disease (IBD). Targeting these cytokines has some therapeutic benefits, but issues associated with low therapeutic efficacy and immunogenicity for subgroups of patients or IMIDs reduce their clinical use. Therefore, there is an urgent need to improve the coverage and efficacy of antibodies targeting IL-17A and/or IL-17F and IL-17A/F heterodimer. Methods and results Here, we initially identified a bioactive 20 amino acid IL-17A/F-derived peptide (nIL-17) that mimics the pro-inflammatory actions of the full-length proteins. Subsequently, we generated a novel anti-IL-17 neutralising monoclonal antibody (Ab-IPL-IL-17) capable of effectively reversing the pro-inflammatory, pro-migratory actions of both nIL-17 and IL-17A/F. Importantly, we demonstrated th
Source: ard.bmj.comCategories: General Medicine News, Latest HeadlinesTweet-
Novel biologic Ab-IPL-IL-17 shows promise for #rheumatoidarthritis and #inflammatoryboweldisease https://t.co/7iU0sWA6F8 https://t.co/SZs3isaFm5
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Mashup Score: 1Identifying Axial Spondyloarthritis in Patients With Inflammatory Bowel Disease Using Computed Tomography - 10 month(s) ago
Objective The diagnosis of axial spondyloarthritis (axSpA) is hampered by diagnostic delay. Computed tomography (CT) undertaken for nonmusculoskeletal (non-MSK) indications in patients with inflammatory bowel disease (IBD) offers an opportunity to identify sacroiliitis for prompt rheumatology referral. This study aims to identify what proportion of patients with IBD who underwent abdominopelvic…
Source: The Journal of RheumatologyCategories: Latest Headlines, RheumatologyTweet-
Research Article Identifying Axial Spondyloarthritis in Patients With Inflammatory Bowel Disease Using Computed Tomography 📰 https://t.co/fL7bj7MMWs #spondyloarthritis #inflammatoryboweldisease #screeningtool #imaging https://t.co/gW5sjzVy9S
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Mashup Score: 0A Joint Effort: Improving the Identification of Spondyloarthritis in Patients With Inflammatory Bowel Disease - 10 month(s) ago
In individuals with inflammatory bowel disease (IBD), extraintestinal manifestations (EIMs) represent a significant burden of illness, with reported prevalence rates of up to 50%.1 Of the various types of EIMs, the most commonly involved organ system is the musculoskeletal system. The 2 major clinical phenotypes are axial spondyloarthritis (axSpA) and peripheral SpA, which have been reported in…
Source: The Journal of RheumatologyCategories: Latest Headlines, RheumatologyTweet-
Editorial A Joint Effort: Improving the Identification of Spondyloarthritis in Patients With Inflammatory Bowel Disease 📰 https://t.co/bnRXDXLsVu #spondyloarthritis #inflammatoryboweldisease https://t.co/5wLk72r35l
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Mashup Score: 0Long-term Risk of Stroke in Patients With Inflammatory Bowel Disease: A Population-Based, Sibling-Controlled Cohort Study, 1969–2019 - 10 month(s) ago
Background and Objectives: Patients with inflammatory bowel disease (IBD) are at an increased risk of thromboembolic events, but evidence on the long-term risk of stroke remains scarce. We aimed to explore whether patients with a biopsy-confirmed IBD had an increased long-term risk of stroke. Methods: This cohort included all biopsy-confirmed IBD patients in Sweden between 1969 and 2019, as well…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Via @GreenJournal: Patients with #InflammatoryBowelDisease had an increased risk of stroke that remained even 25 years after their diagnosis: https://t.co/4h2AGYLw5J #neurotwitter #IBD @AANMember https://t.co/1AmHoJz5vm
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Mashup Score: 7Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial - 10 month(s) ago
AbstractBackground. Human hookworm has been proposed as a treatment for ulcerative colitis (UC). This pilot study assessed the feasibility of a full-scale rando
Source: OUP AcademicCategories: General Medicine News, Latest HeadlinesTweet-
'Infect and forget': A dose of hookworms could help patients manage #inflammatoryboweldisease https://t.co/h3hQed13vq https://t.co/yy4Igy0hY4
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Study identifies promising target for treating #inflammatoryBowelDisease and colitis-induced colorectal cancers @UWMadison @JCI_Insight https://t.co/W4uTBqRzhS https://t.co/pCcOUuiEeI