• Mashup Score: 1

    Objective Bile acid diarrhoea (BAD) is debilitating yet treatable, but it remains underdiagnosed due to challenging diagnostics. We developed a blood test-based method to guide BAD diagnosis. Design We included serum from 50 treatment-naive patients with BAD diagnosed by gold standard 75selenium homotaurocholic acid test, 56 feature-matched controls and 37 patients with non-alcoholic fatty liver…

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  • Mashup Score: 2

    Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn’s disease and ulcerative colitis. By characterising metabolites in faeces, combined with faecal metagenomics, host genetics and clinical characteristics, we aimed to unravel metabolic alterations in IBD. Design We measured 1684 different faecal metabolites and 8…

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    • RT @Metabbot: Faecal metabolome and its determinants in inflammatory bowel disease. Gut #metabolomics https://t.co/ydSNBg8Sky

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    AbstractAims. Observational studies of diet in cardiometabolic-cardiovascular disease (CM-CVD) focus on self-reported consumption of food or dietary pattern, wi

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    • .@NIH_NHLBI-funded study shows that metabolic signatures of #diet are associated with long-term cardiometabolic-#cardiovascular disease independent of #lifestyle & traditional #risk factors. #CARDIA #Metabolomics #precision #pathways https://t.co/SokWAnSBHd https://t.co/inPOoWIWD6

  • Mashup Score: 4

    Background Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-formylmethionine is associated with increases in metabolomic shift-related metabolites and increases in 28-day mortality. Methods We performed metabolomics analyses on plasma from…

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    • #CritCare #OpenAccess Circulating #N_formylmethionine promotes a #metabolic shift with heightened #mortality https://t.co/BhkkK9xLUr @jlvincen @ISICEM #FOAMed #FOAMcc #metabolomics #critical_illness https://t.co/GbmVFS0sqt