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Mashup Score: 1Going to the dark(er) side: Stanford Medicine study shows how cancer gene tricks immune cells - 1 year(s) ago
A novel Stanford School of Medicine partnership uncovers a direct link between a cancer-associated gene, Myc, and sugar patterns on cancer cell surfaces that tell immune cells to stand down.
Source: News CenterCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes - 1 year(s) ago
Abstract. Small-cell lung cancer is an aggressive neuroendocrine lung cancer. Oncogenic MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC amplification and phenotypic plasticity, characterized by neuroendocrine and non-neuroendocrine cell states is not known. Here, we integrate whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and…
Categories: Hem/Oncs, Latest HeadlinesTweet-
SCLC is an aggressive tumor. #MYC amplification is a driver of #SCLC heterogeneity. Extra-chromosomal DNAs bring to proximity enhancers & oncogenes, creating transcription-amplifying units, driving high MYC gene dosage. This can be seen in #liquidbiopsies https://t.co/dHKke78kzO https://t.co/9DGTqykrf8
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Mashup Score: 2
Abstract. Relapse is the leading cause of death in patients with medulloblastoma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RT @EANOassociation: Dormant #SOX9-positive cells facilitate #MYC-driven recurrence of #medulloblastoma. https://t.co/PkdtjSr5O0 #btsm @CR…
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Mashup Score: 2
The germline polymorphism rs55705857-G was identified as the causal variant in IDH-mutant glioma.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RT @EANOassociation: A Germline Variant Deregulates #MYC Expression in #IDH1-Mutant #Glioma. https://t.co/hsrVA0IrFc #btsm @CD_AACR @Scien…
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Mashup Score: 1
Abstract. Relapse is the leading cause of death in patients with medulloblastoma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk…
Categories: Hem/Oncs, Latest HeadlinesTweet-
RT @EANOassociation: Dormant #SOX9-positive cells facilitate #MYC-driven recurrence of #medulloblastoma. https://t.co/PkdtjSr5O0 #btsm @CR…
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Mashup Score: 1
The germline polymorphism rs55705857-G was identified as the causal variant in IDH-mutant glioma.
Categories: Hem/Oncs, Latest HeadlinesTweet-
RT @EANOassociation: A Germline Variant Deregulates #MYC Expression in #IDH1-Mutant #Glioma. https://t.co/hsrVA0IrFc #btsm @CD_AACR @Scien…
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Mashup Score: 0
MYC is a transcription factor frequently overexpressed in cancer. To determine how MYC drives the neoplastic phenotype, we performed transcriptomic analysis using a panel of MYC-driven autochthonous transgenic mouse models. We found that MYC elicited gene expression changes mostly in a tissue- and lineage-specific manner across B-cell lymphoma, T-cell acute lymphoblastic lymphoma, hepatocellular…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In our latest issue @DelaneyKSull, @renumathyd& co-workers look across multiple MYC-driven transgenic mouse models & show that #MYC oncogene promotes tissue dedifferentiation in #tumorigenesis 👉https://t.co/BFOt2IiPnB
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Mashup Score: 8
MYC hyperactivation through genome amplification or transcriptional induction promotes a proinvasive tumor microenvironment and a more highly metastatic state in pancreas cancer.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the February issue: #MYC levels regulate #metastatic heterogeneity in pancreatic adenocarcinoma by @MaddipatiLab, Ben Stanger et al. https://t.co/vnQi3qv0vH @utswcancer @PennMedicine @PennCancer https://t.co/waTQeJj7rf
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Mashup Score: 3
The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic leukemia (T-ALL) but a common pathway to target this circuit is poorly defined. Bromodomain-containing protein 4 (BRD4) is implicated to have a role in the transcriptional regulation of oncogenes MYC and targets downstream of…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Targeting the #NOTCH1-#MYC-#CD44 axis in leukemia-initiating cells in T-ALL | @LeukemiaJnl | Led by .@GBorthakur & team | @DrHKantarjian @MDAndersonNews #endcancer #leusm #lymsm #BETi #BRDi #BRD4 https://t.co/HPIFSe9gqz
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Mashup Score: 8
This Perspective highlights the importance of protein–protein interactions for the oncogenic functions of MYC and discusses how the MYC protein interactome might be exploited therapeutically.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In our September issue: MYC protein interactors in gene transcription and cancer, by Linda Z. Penn et al. https://t.co/GsA52KB6XY @NatresCancer @pmcancercentre @MBPatUofT #MYC #proteinInteractome #transcription https://t.co/NBU3QhHdo6
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RT @Rndubois: Direct link between #Myc and #sugar in #cancer: https://t.co/1s24yPiIAP