• Mashup Score: 3

    emotherapy and has significant negative consequences on the quality of life of survivors. Current treatment options for CIPNP are limited and unsatisfactory. TRPM3 is a calcium-permeable ion channel functionally expressed in peripheral sensory neurons involved in the detection of thermal stimuli. Here, we focus on the possible involvement of TRPM3 in acute oxaliplatin-induced mechanical allodynia and cold hypersensitivity. In vitro calcium microfluorimetry and whole-cell patch-clamp experiments showed that TRPM3 is functionally upregulated in both heterologous and homologous expression systems after acute (24 hours) oxaliplatin treatment, whereas the direct application of oxaliplatin was without effect. In vivo behavioral studies using an acute oxaliplatin model for CIPNP showed the development of cold and mechano hypersensitivity in control mice, which was lacking in TRPM3 deficient mice. In addition, the levels of protein ERK, a marker for neuronal activity, were significantly reduce

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    • Read an article in #PAIN highlighting #TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral #neuropathicpain. https://t.co/JKqeo03A5V

    • Read an article in #PAIN highlighting #TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral #neuropathicpain. https://t.co/QVVHVgltnG

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    The NeuPSIG 2023 International Congress is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of neuropathic pain. This meeting brings together key stakeholders in neuropathic pain to discuss, network, and strengthen scientific collaboration.

    Tweet Tweets with this article
    • Join the #NeuPSIG2023 conversation, share photos, and meeting highlights. #NeuPSIG2023 is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of #neuropathicpain. https://t.co/DM7K1c7bmA https://t.co/a6g6gBUfHd

    • Join the #NeuPSIG2023 conversation, share photos, and meeting highlights. #NeuPSIG2023 is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of #neuropathicpain. https://t.co/sDuS302Ltw https://t.co/jOJU5nINFs

  • Mashup Score: 0

    The NeuPSIG 2023 International Congress is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of neuropathic pain. This meeting brings together key stakeholders in neuropathic pain to discuss, network, and strengthen scientific collaboration.

    Tweet Tweets with this article
    • Day three of #NeuPSIG203 features plenary sessions by leading experts in the field of #neuropathicpain, including Ulrike Bingel, @cfaber3, Scott Lempka, and @GaryRLewin1. https://t.co/sDuS302Ltw https://t.co/VRIoHfk2H4

    • Day three of #NeuPSIG203 features plenary sessions by leading experts in the field of #neuropathicpain, including Ulrike Bingel, @cfaber3, Scott Lempka, and @GaryRLewin1. https://t.co/DM7K1c7bmA https://t.co/C2D9URmKBk

  • Mashup Score: 0

    The NeuPSIG 2023 International Congress is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of neuropathic pain. This meeting brings together key stakeholders in neuropathic pain to discuss, network, and strengthen scientific collaboration.

    Tweet Tweets with this article
    • Join the #NeuPSIG2023 conversation, share photos, and meeting highlights. #NeuPSIG2023 is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of #neuropathicpain. https://t.co/sDuS302Ltw https://t.co/RlJdk0IIbF

    • Join the #NeuPSIG2023 conversation, share photos, and meeting highlights. #NeuPSIG2023 is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of #neuropathicpain. https://t.co/DM7K1c7bmA https://t.co/Am4UVQ424q

  • Mashup Score: 0

    The NeuPSIG 2023 International Congress is the leading meeting for the latest research and developments in understanding the mechanisms, assessment, prevention, and treatment of neuropathic pain. This meeting brings together key stakeholders in neuropathic pain to discuss, network, and strengthen scientific collaboration.

    Tweet Tweets with this article
    • Day two of #NeuPSIG203 features plenary sessions by leading experts in the field of #neuropathicpain, including @pall_karlsson, Daniela Maria Menichella, and @UTDPainLab. https://t.co/sDuS302Ltw https://t.co/HPQoF07nwm

    • Day two of #NeuPSIG203 features plenary sessions by leading experts in the field of #neuropathicpain, including @pall_karlsson, Daniela Maria Menichella, and @UTDPainLab. https://t.co/DM7K1c7bmA https://t.co/czDcmpK8e9

  • Mashup Score: 0

    This presentation will provide a brief overview of the widening split between the advances in our understanding of the pathophysiological and cellular mechanisms of neuropathic pain (NP) and the clinical therapies for NP, which highlights the unmet needs from the patient and provider perspectives. A hypothesis will be presented that in many neuropathic pain conditions, the peripheral nervous system (PNS) is a promising target site for developing safe and efficacious new pharmacologic therapies. This view will be supported by neurophysiologic studies in humans suggesting that spontaneous and ectopic activity in the PNS may be the spark which is amplified in the CNS and kindles the wildfire that contributes to the development and maintenance of NP.  Additional evidence will be discussed, which indicates that blocking this peripheral input leads to pain relief in patients with chronic NP. Neurophysiologic studies in DRGs from patients with neuropathic pain and pluripotent stem cells from

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    • Day one of #NeuPSIG2023 features a keynote plenary session by a leading expert in the field of #neuropathicpain, @DrRajaHopkins, presenting the J. Edmond Charlton lecture, Peripheral Nervous System Targets for Treating Neuropathic Pain. https://t.co/zZJ4HoX3Er

    • Day one of #NeuPSIG2023 features a keynote plenary session by a leading expert in the field of #neuropathicpain, @DrRajaHopkins, presenting the J. Edmond Charlton lecture, Peripheral Nervous System Targets for Treating Neuropathic Pain. https://t.co/cXexPIFLuT

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    Register to Attend NeuPSIG 2023, 7-9 September in Lisbon, Portugal: neupsig2023.org

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    • #NeuPSIG2023 keynote plenary speaker @DrRajaHopkins of @HopkinsPain provides insight into his topic at the leading meeting on #neuropathicpain, 7-9 September, in Lisbon, Portugal. Register now. https://t.co/9b4ejsjjAW

    • #NeuPSIG2023 keynote plenary speaker @DrRajaHopkins of @HopkinsPain provides insight into his topic at the leading meeting on #neuropathicpain, 7-9 September, in Lisbon, Portugal. Register now. https://t.co/hScu7NWs7G

  • Mashup Score: 0

    Register to Attend NeuPSIG 2023, 7-9 September in Lisbon, Portugal: neupsig2023.org

    Tweet Tweets with this article
    • #NeuPSIG2023 keynote plenary speaker @DrRajaHopkins of @HopkinsPain provides insight into his topic at the leading meeting on #neuropathicpain, 7-9 September, in Lisbon, Portugal. Register now. https://t.co/hScu7NWs7G

    • #NeuPSIG2023 keynote plenary speaker @DrRajaHopkins of @HopkinsPain provides insight into his topic at the leading meeting on #neuropathicpain, 7-9 September, in Lisbon, Portugal. Register now. https://t.co/9b4ejsjjAW

  • Mashup Score: 0

    The trails through our public lands weren’t designed for wheelchairs, but new wheelchairs are designed for those trails. National Park Service accessibility specialist Quinn Brett wants parks to catch up with wheelchair technology, increasing access to American wilderness.

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    • What good's it do if one is in too much #pain to get showered, dressed, out of the house, into the car, out of the car, and into a #wheelchair? Asking for a friend.. https://t.co/n51skSI322 #ChronicPain #NeuropathicPain #disability #hiking @PBS