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Mashup Score: 12CD19 CAR T-cell therapy and prophylactic anakinra in relapsed or refractory lymphoma: phase 2 trial interim results - Nature Medicine - 9 month(s) ago
Prophylactic subcutaneous administration of anakinra, an IL-1 receptor inhibitor, reduced severe immune effector cell-associated neurotoxicity syndrome incidence in patients with relapsed or refractory large B-cell and mantle cell lymphoma treated with anti-CD19 chimeric antigen receptor (CAR) T cells.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes - 1 year(s) ago
Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common complication of cancer treatment that produces functional disability. Increasingly, patient-reported outcome measures (PROMs) are used to assess CIPN, providing a broader symptom perspective than clinician-graded scales. Understanding when a reported change in CIPN symptoms meets the threshold for clinical significance…
Source: JNCCNCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Researchers have discovered a link between neurotoxicity related to chimeric antigen receptor T-cell therapy and development of subsequent hypophosphatemia.Results of their prospective analysis, published in Cancer Immunology Research, suggest incidence and severity of CAR T-cell therapy complication known as immune effector cell-associated neurotoxicity syndrome (ICANS) are associated with
Source: www.healio.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0CAR T-Cell Therapy Neurotoxicity Linked to NfL Elevations - 1 year(s) ago
Patients who develop potentially serious neurotoxicity show elevated plasma levels of neurofilament light chain prior to the treatment, suggesting it could be predictor of risk for this side effect.
Source: MedscapeCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 0
Leaded gas was banned in 1996, but exposure to the poison cost people born before then several IQ points on average, researchers estimated.
Source: NBC NewsCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Chronic exposure to high levels of manganese (Mn) leads to manganism, a neurological disorder with similar symptoms to those inherent to Parkinson’s disease. However, the underlying mechanisms of this pathological condition have yet to be established. Since the human excitatory amino acid transporter 2 (EAAT2) (glutamate transporter 1 in rodents) is predominantly expressed in astrocytes and its…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 1Inici sessió - Identificació UB - Universitat de Barcelona - 2 year(s) ago
Identifiqueu-vos amb el nom d’usuari i la contrasenya de la Intranet UB. Començareu una sessió que us donarà accés als serveis de la Universitat que requereixen identificació UB Per poder autenticar-vos és necessari introduir correctament la targeta amb el…
Source: sso.ub.eduCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 4
Objective: To examine the relationship between transcranial doppler (TCD) mean flow velocity (MFV) and the severity and temporal onset of neurotoxicity after chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed lymphoma. Methods: We identified a cohort of 165 patients with relapsed or refractory B-cell lymphoma who received CAR T-cell therapy. TCDs were performed at baseline,…
Source: Neurology Clinical PracticeCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 0Weekly Paclitaxel‐Induced Neurotoxicity in Breast Cancer: Outcomes and Dose Response - 3 year(s) ago
The Oncologist is committed to helping physicians excel in the constantly changing fields of oncology and hematology through the publication of timely reviews, original studies, and commentaries on important developments.
Source: The OncologistCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Wolters Kluwer Health - 3 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable…
Source: journals.lww.comCategories: Latest Headlines, NeurologyTweet
CAR T cell therapy made safer by preventing #neurotoxicity. An MSK team led by @jaeparkmd used a drug called anakinra to reduce severe neurotoxicity incidence in #lymphoma patients treated with anti-CD19 #CARTcells. https://t.co/unCubPdKwU