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    The caudal ventrolateral medulla was thought to be involved in pain control, but its pathway was unknown. Here, Gu et al. identify the molecular components of a caudal ventrolateral medulla–locus coeruleus–spinal cord pathway and show it has a role in counter-stimulus pain control.

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    • Neurons in the caudal ventrolateral medulla mediate descending #pain control https://t.co/DztGCrawxC #VentroLateralMedullla #cVLM #LocusCoeruleus #SpinalCord #Noradrenergic #Norepinephrine #DescendingPathway #Allodynia #ChronicPain https://t.co/NtnIa1lKDW https://t.co/eeI26mWbUO

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    Up to 80% of people with dementia experience pain. Learn how to recognize it and advocate for pain management for your loved one.

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    • What happens if mentally unfit to voice capably? #Dementia-related #pain: What caregivers need to know https://t.co/Lak7l5KOjq #Alzheimer #ChronicPain #locuscoeruleus #norepinephrine #neuroinflammation #PAINAD https://t.co/UDPUUXA30x https://t.co/OuUZe1EIj3

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    A new study shows that infra-slow cortical norepinephrine oscillations shape the micro-structure of sleep and transitions to micro-arousals, wakefulness or rapid eye movement (REM) sleep. Prolonged descending phases of these oscillations promote the occurrence of spindle-rich intermediate sleep, which is involved in memory consolidation.

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    • Infra-slow cortical #norepinephrine oscillations during #sleep shape transitions to micro-arousals, wakefulness, or REM sleep. Prolonged descending phases of these oscillations promote spindle-rich intermediate sleep, involved in memory consolidation https://t.co/Xag6cvfm7Z

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    Kjaerby and Andersen et al. show that norepinephrine (NE) plays profound roles in shaping sleep micro-architecture. NE slowly oscillates during sleep, with NE oscillatory amplitude being a major determinant of spindle-dependent memory consolidation and awakenings.

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    • #Norepinephrine (NE) oscillations shape #sleep micro-architecture related to #memory performance: prolonged descent of NE promotes spindles and REM sleep but also associates with awakenings, whereas shorter NE descents uphold NREM sleep and micro-arousals https://t.co/yZSrYunktg

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    Venous return is the flow of blood from the systemic venous network towards the right heart. At steady state, venous return equals cardiac output, as the venous and arterial systems operate in series. However, unlike the arterial one, the venous network is a capacitive system with a high compliance. It includes a part of unstressed blood, which is a reservoir that can be recruited via sympathetic…

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    • #CritCare #OpenAccess #VenousReturn: how does #Guyton’s #physiology help understand the effects on #CardiacOutput of common treatments used in critically ill patient? https://t.co/Kyx7qmrbF7 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Norepinephrine #lung #heart #FluidTherapy https://t.co/eKgSAFlaGv

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    Thematic Series After so many negative randomized, controlled trials, that have evaluated a number of simplified therapeutic interventions that could be applied to large patient populations, people are turning their interest back to personalized medicine.This new Thematic Series will share thoughts based on scientific data and help the clinician to individualize the…

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    • #CritCare #OpenAccess TC: “#PERSONALIZED_MEDICINE IN THE #ICU” https://t.co/7fpW65xtlP @Vasopressin in #septic_shock: when starting? https://t.co/fO8WSAJMto @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #sepsis #norepinephrine #pharmacokinetics https://t.co/xgmI2Ce8Pm

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    Background Through venous contraction, norepinephrine (NE) increases stressed blood volume and mean systemic pressure (Pms) and exerts a “fluid-like” effect. When both fluid and NE are administered, Pms may not only result from the sum of the effects of both drugs. Indeed, norepinephrine may enhance the effects of volume expansion: because fluid dilutes into a more constricted, smaller, venous…

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    • #CritCare #OpenAccess https://t.co/GnyaDwUW6y The #haemodynamic effect of #norepinephrine during #septic_shock #FOAMed #FOAMcc #BMC #ICU #IntensiveCare #Pms #leg_rising #fluid @jlvincen @ISICEM @of_aic https://t.co/C0EZuYdH9e