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Mashup Score: 0Evidence of a genetic background predisposing to complex regional pain syndrome type 1 - 7 month(s) ago
Background Complex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. This exploratory study examined whether patients with chronic CRPS-1 have a different genetic profile compared with those who do not have the condition. Methods Exome sequencing was performed to seek altered non-synonymous SNP allele frequencies in a discovery cohort of well-characterised patients with chronic CRPS-1 (n = 34) compared with population databases. Identified SNP alleles were confirmed by Sanger sequencing and sought in a replication cohort (n = 50). Gene expression of peripheral blood macrophages was assessed. Results In the discovery cohort, the rare allele frequencies of four non-synonymous SNPs were statistically increased. The replication cohort confirmed this finding. In a chronic pain cohort, these alleles were not overexpressed. In total, 25 out of 84 (29.8%) patients with CRPS-1 expressed a rare allele. The SNPs were rs41289
Source: jmg.bmj.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0Current Issue : PAIN - 7 month(s) ago
PAIN publishes research on the nature, mechanisms and treatment of pain. The journal provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet-
The latest issue of #PAIN is now available. Dive into the most recent articles on #painresearch. https://t.co/5qWgLTrpiE https://t.co/W0qEjdDO5l
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The latest issue of #PAIN is now available. Dive into the most recent articles on #painresearch. https://t.co/wT0UJLoQNj https://t.co/5rhTp2qxc9
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The latest issue of #PAIN is now available. Dive into the most recent articles on #painresearch. https://t.co/wT0UJLoQNj https://t.co/oDpQ835PKB
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Mashup Score: 0A systematic review of genome-wide association studies for... : PAIN - 7 month(s) ago
l differences in pain treatment response. To better understand the underlying genetic mechanisms of pain, we systematically reviewed and summarized genome-wide association studies (GWASes) investigating the associations between genetic variants and pain/pain-related phenotypes in humans. We reviewed 57 full-text articles and identified 30 loci reported in more than 1 study. To check whether genes described in this review are associated with (other) pain phenotypes, we searched 2 pain genetic databases, Human Pain Genetics Database and Mouse Pain Genetics Database. Six GWAS-identified genes/loci were also reported in those databases, mainly involved in neurological functions and inflammation. These findings demonstrate an important contribution of genetic factors to the risk of pain and pain-related phenotypes. However, replication studies with consistent phenotype definitions and sufficient statistical power are required to validate these pain-associated genes further. Our review also
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet-
Take part in #PAM2023 and discover the latest articles featured in #PAIN focused on the theme of #painresearch. Read an article discussing genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. https://t.co/1XBQ9SalD2 https://t.co/TqiwpvLXnr
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Take part in #PAM2023 and discover the latest articles featured in #PAIN focused on the theme of #painresearch. Read an article discussing genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. https://t.co/YBhsI0M80j https://t.co/LntsL0zhwx
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Mashup Score: 0Current Issue : PAIN - 7 month(s) ago
PAIN publishes research on the nature, mechanisms and treatment of pain. The journal provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet-
Celebrate #PAM2023 with @PaintheJournal, the number one journal dedicated to pain. Check out the latest issue and share your favorite articles to help raise awareness of #painresearch https://t.co/eZHvxR0Fwy https://t.co/EGVoNdQZLw
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Celebrate #PAM2023 with @PaintheJournal, the number one journal dedicated to pain. Check out the latest issue and share your favorite articles to help raise awareness of #painresearch https://t.co/U7sH8t1wOB https://t.co/E1WWCvNIuZ
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Mashup Score: 0
MDA, Pain Research Consortium Conference, 10/27/2023 7:30:00 AM – 10/27/2023 4:30:00 PM, The Pain Consortium Conference serves as a unique platform for collaboration and networking among Pain Sciences professionals. Bringing together experts from diverse backgrounds, this conference fosters interdisciplinary discussions on cutting-edge research in both clinical and basic sciences. With a focus on bridging gaps between different departments working on pain, the conference aims to stimulate new research projects and promote a holistic understanding of pain after cancer treatment. By removing silos in pain research, this gathering of experiences seeks to cultivate innovative solutions and advance patient care. Join us for a transformative event that combines scientific exploration, collaborative networking, and the opportunity to shape the future of pain management.
Source: mdanderson.cloud-cme.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Join interdisciplinary discussions on cutting-edge research in both clinical and basic sciences at our Pain Research Consortium, Saturday, Oct. 27. Register today: https://t.co/cKzeB134e2 #PainResearch #CME #EndCancer https://t.co/3U3N0HBCt6
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Mashup Score: 0Current Issue : PAIN - 7 month(s) ago
PAIN publishes research on the nature, mechanisms and treatment of pain. The journal provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet-
As part of the #PAM2023 theme #painresearch, IASP invites you to share your favorite articles from the September issue of #PAIN to help raise awareness around #painresearch, what it is, and why it is important. https://t.co/U7sH8t1wOB https://t.co/ofcmK6WpxV
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As part of the #PAM2023 theme #painresearch, IASP invites you to share your favorite articles from the September issue of #PAIN to help raise awareness around #painresearch, what it is, and why it is important. https://t.co/eZHvxR0Fwy https://t.co/yJaveKCi4E
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Mashup Score: 0A systematic review of genome-wide association studies for... : PAIN - 7 month(s) ago
l differences in pain treatment response. To better understand the underlying genetic mechanisms of pain, we systematically reviewed and summarized genome-wide association studies (GWASes) investigating the associations between genetic variants and pain/pain-related phenotypes in humans. We reviewed 57 full-text articles and identified 30 loci reported in more than 1 study. To check whether genes described in this review are associated with (other) pain phenotypes, we searched 2 pain genetic databases, Human Pain Genetics Database and Mouse Pain Genetics Database. Six GWAS-identified genes/loci were also reported in those databases, mainly involved in neurological functions and inflammation. These findings demonstrate an important contribution of genetic factors to the risk of pain and pain-related phenotypes. However, replication studies with consistent phenotype definitions and sufficient statistical power are required to validate these pain-associated genes further. Our review also
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet-
Take part in #PAM2023 and discover the latest articles featured in #PAIN focused on the theme of #painresearch. Read an article discussing genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. https://t.co/1XBQ9SalD2 https://t.co/xcBu1pBpnU
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Take part in #PAM2023 and discover the latest articles featured in #PAIN focused on the theme of #painresearch. Read an article discussing genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. https://t.co/YBhsI0M80j https://t.co/HF2OGx1Fsv
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Mashup Score: 0Current Issue : PAIN - 7 month(s) ago
PAIN publishes research on the nature, mechanisms and treatment of pain. The journal provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet-
For #PAM2023 discover the latest #painresearch articles featured in #PAIN. Share the articles that interest you with your followers and join the conversation around #painresearch and #paintrials to raise awareness. https://t.co/eZHvxR0Fwy https://t.co/eamrYajiUO
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For #PAM2023 discover the latest #painresearch articles featured in #PAIN. Share the articles that interest you with your followers and join the conversation around #painresearch and #paintrials to raise awareness. https://t.co/U7sH8t1wOB https://t.co/ubcmrZzhdg
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Mashup Score: 0
Pain Research Forum Navigation CONTENT Join Us Fostering discussion and collaboration that speeds up the acquisition of new knowledge and its translation into novel pain treatments.  PRF News See […]
Source: www.iasp-pain.orgCategories: Latest Headlines, RheumatologyTweet-
This #PAM2023, discover groundbreaking #painresearch within the @PainResForum. Explore IASP's PRF, your gateway to cutting-edge knowledge and transformative pain treatments. Uncover resources, research articles, and dynamic discussions. https://t.co/twGPvj7bNs https://t.co/2xQ8AMWUXp
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This #PAM2023, discover groundbreaking #painresearch within the @PainResForum. Explore IASP's PRF, your gateway to cutting-edge knowledge and transformative pain treatments. Uncover resources, research articles, and dynamic discussions. https://t.co/lOA7HwUmZh https://t.co/sSCxz9sZdf
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Mashup Score: 0
Pain Research Forum Navigation CONTENT Join Us Fostering discussion and collaboration that speeds up the acquisition of new knowledge and its translation into novel pain treatments.  PRF News See […]
Source: www.iasp-pain.orgCategories: Latest Headlines, RheumatologyTweet-
As part of the #PAM2023 #painresearch theme, @IASPpain highlights the @PainResForum, the place for fostering discussion and collaboration to speed the acquisition of new knowledge and its translation into novel treatments for pain. #paintrials https://t.co/lOA7HwUmZh https://t.co/YjTlvBt4b6
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As part of the #PAM2023 #painresearch theme, @IASPpain highlights the @PainResForum, the place for fostering discussion and collaboration to speed the acquisition of new knowledge and its translation into novel treatments for pain. #paintrials https://t.co/twGPvj7bNs https://t.co/EHTyJUA8zr
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New study in @JMG_BMJ: Genes linked to 1 in 3 cases of complex regional pain syndrome (CRPS) 🧬 Surprisingly, men carry more genetic variants but are less likely to develop syndrome. #CRPS #Genetics #PainResearch Read full article here: https://t.co/a8ahAEyaCW