• Mashup Score: 2
    Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis - 2 year(s) ago

    Extracellular cold-inducible RNA binding protein (eCIRP) is an inflammatory mediator that causes inflammation and tissue injury in sepsis. Gasdermin D (GSDMD) is a protein that, when cleaved, forms pores in the cell membrane, releasing intracellular contents into the extracellular milieu to

    Source: The Journal of Immunology
    Categories: Allergy-Immunology, Latest Headlines
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      J_Immunol

      Active Release of eCIRP via #GasderminD Channels Induce #Inflammation in #Sepsis from Ping Wang at The Feinstein Institutes @NorthwellHealth #ReadTheJI #CellDeath #Pyroptosis #Caspase #BacterialImmunity https://t.co/4HRPPtfWuc https://t.co/m8BhE8KOQy

  • Mashup Score: 10
    Please wait whilst we redirect you - 3 year(s) ago

    About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2021 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V.

    Source: www.sciencedirect.com
    Categories: Allergy-Immunology, Latest Headlines
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      ImmunityCP

      .@jkagan1, @VirulentMind &co: Bcl-2 family members Mcl-1 and Bcl-xL act as guard proteins of virus-mediated protein synthesis inhibition & trigger #pyroptosis upon inactivation https://t.co/boHgl63lnk @AleksProchera https://t.co/lAWMMky573

  • Mashup Score: 4
    Emerging connectivity of programmed cell death pathways and its physiological implications - 4 year(s) ago

    Dispensable, infected or neoplastic cells are removed by programmed cell death, including pathways for apoptosis, necroptosis and pyroptosis. Owing to differences in their mechanisms and physiological outcomes, these cell death pathways have traditionally been viewed as separate entities, but it has become clear that they are mechanistically and functionally connected.

    Source: Nature Reviews Molecular Cell Biology
    Categories: Allergy-Immunology, Latest Headlines
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      NatRevMCB

      Cell death pathways are interconnected! Check out our new #Review by Andreas Strasser and co. @TheDohertyInst @MarcoHerold_J @WEHI_research #CellDeath #Apoptosis #Necroptosis #Pyroptosis Go here: https://t.co/193kItfYje https://t.co/0yzSMJ7zyU

  • Mashup Score: 0
    The role of inflammasomes in kidney disease - 4 year(s) ago

    In this Review, the authors discuss the biology of canonical and non-canonical inflammasomes and inflammasome-forming genes in the kidney, including their different functions in the various kidney compartments and their potential as therapeutic targets.

    Source: Nature Reviews Nephrology
    Categories: Latest Headlines, Nephrology
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      NatRevNeph

      The interaction between #inflammasomes and #pyroptosis. https://t.co/MgfsxM0ob1 https://t.co/KW8fRJNtkT

  • Mashup Score: 3
    Cell death in the gut epithelium and implications for chronic inflammation - 4 year(s) ago

    Evidence points to a crucial role of necroptosis and pyroptosis as important modes of programmed cell death in the intestine in addition to apoptosis. This Review discusses advances in our understanding of apoptosis, necroptosis and pyroptosis as major cell death pathways that can result in pathophysiological outcomes.

    Source: Nature Reviews Gastroenterology & Hepatology
    Categories: Gastroenterology, Latest Headlines
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      NatRevGastroHep

      REVIEW | Cell death in the gut epithelium and implications for chronic inflammation by Jay V. Patankar & Christoph Becker https://t.co/T3UvDf8mQe https://t.co/Wvo57VjMw1

    • Profile photo of NatRevGastroHep
      NatRevGastroHep

      In this new Review on mechanisms of #CellDeath in the gut epithelium, the authors examine translational aspects of cell death modulation for the development of novel therapeutic alternatives for #IBD and #ColorectalCancer. Read more here: https://t.co/T3UvDf8mQe https://t.co/E86ODghyRP

    • Profile photo of NatRevGastroHep
      NatRevGastroHep

      ICYMI | New Review online! Jay Patankar & Christoph Becker discuss #CellDeath in the gut epithelium and advances in our understanding of #apoptosis, #necroptosis and #pyroptosis as major cell death pathways that result in pathophysiological outcomes. https://t.co/T3UvDf8mQe https://t.co/X6FVfyKO7h

  • Mashup Score: 72
    Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19 - 4 year(s) ago

    The inflammatory response to severe acute respiratory syndrome–related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. Of the many innate immune pathways that are engaged by severe acute respiratory syndrome–related coronavirus 2, we highlight the importance of the inflammasome pathway. We discuss available pharmaceutical agents that…

    Source: The Journal of Immunology
    Categories: Healthcare Professionals, Latest Headlines
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    • Profile photo of VirusesImmunity
      VirusesImmunity

      Back in April, I tweeted this thread explaining my thoughts about the role of #inflammasomes & #pyroptosis in #COVID19. Seeing this, @jeremymmunology reached out to me about writing a review together. Now, I'm delighted to share our review @J_Immunol https://t.co/dV4qan1o1u https://t.co/BMts4DdLeR https://t.co/HOTrlYuy1J

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