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Mashup Score: 5#Tcells - Healthcare Social Media Analytics and Transcripts - 2 month(s) ago
What is #Tcells? AIDS, Cancer, HIV, hiv/aids, immune cells, Immune-Mediated Inflammatory Diseases, immunity, Immunology, Oncology, SARS-CoV-2 Variants, tcells. Healthcare Social Media Hashtag. Real-time Analytics.
Source: www.symplur.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 221Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants - 2 month(s) ago
Genetic variants associated with disease risk manifest activation and cell type–dependent effects on gene expression in immune cells.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 88Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling - 2 month(s) ago
Tonic T cell receptor signals trigger negative feedback that restrains naive T cell responsiveness.
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 19Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice - 3 month(s) ago
Nature Communications – The origin of SARS-CoV-2 cross-reactive T cells in unexposed humans is unclear. Here, the authors use HLA transgenic mouse models of sequential infections with human…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 14The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates - 3 month(s) ago
Nature Immunology – Xue and colleagues show that the transcription cofactor Tle3 cooperates with Runx3, Tcf1 and Tbet to limit a central memory and promote an effector memory cell signature in CD8+…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 13Progressively Enhancing Stemness of Adoptively Transferred T Cells with PI3Kδ Blockade Improves Metabolism and Antitumor Immunity - 3 month(s) ago
Elevating T-cell stemness by progressively blocking PI3Kδ signaling during ex vivo manufacturing of adoptive cell therapies alters metabolic and functional properties to enhance antitumor immunity dependent on Tcf1 and Lef1.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 6Fatty Acids Invigorate Tumor-Resident Memory T Cells - 6 month(s) ago
Abstract. Tissue-resident memory T cells (Trm) represent a diverse cell type with tissue-specific gene signatures that can operate as both effector and memory T cells. Trm cells play a crucial role in immune defense against infections and cancer. Recently, Trm cells have become appreciated as a critical responder to checkpoint immunotherapy and as a biomarker of favorable outcomes in cancer. Hence, it is of great clinical and therapeutic importance to investigate how Trm cells can be manipulated transcriptionally, epigenetically, or metabolically to improve their longevity and function. In this issue of Cancer Research, Feng and colleagues demonstrate that the transcription factor SCML4 is essential for the development and polyfunctionality of Trm cells. Fatty acids mediated the upregulation of SCML4 via the mTOR–IRF4–PRDM1 signaling pathway, which significantly enhanced tumor control in multiple aggressive murine tumor models and was associated with a favorable prognosis for patients
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 10Fatty Acids Support the Fitness and Functionality of Tumor-Resident CD8+ T Cells by Maintaining SCML4 Expression - 6 month(s) ago
SCML4 upregulation in CD8+ Trm cells and tumor-infiltrating lymphocytes induced by fatty acid metabolism enhances antitumor immune responses, providing an immunometabolic axis to target for cancer treatment.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0
CRISPR–Cas9 gene editing in T cells can lead to partial or complete loss of the targeted chromosome.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS - 6 month(s) ago
During viral CNS infection, MyD88 signaling in infected neurons orchestrates recruitment of protective peripheral immune cells.
Source: www.science.orgCategories: Allergy-Immunology, Latest HeadlinesTweet
Top Influencers of #Tcells 👉 @SciImmunology @CornellCFI @Cornell @ONNESHA092 @sciRPatel @abelusmx https://t.co/QXxwmN91cW via @symplur