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Mashup Score: 2Taking on Vasculitis, Together: Meet Rodney and Debbie - 3 month(s) ago
To gain a deeper understanding of their journey with ANCA-associated vasculitis (AAV), Amgen recently sat down with Rodney and Debbie to hear their story and what advice they have for others.
Source: www.amgen.comCategories: General Medicine News, PayerTweet
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Mashup Score: 2Taking on Vasculitis, Together: Meet Rodney and Debbie - 3 month(s) ago
To gain a deeper understanding of their journey with ANCA-associated vasculitis (AAV), Amgen recently sat down with Rodney and Debbie to hear their story and what advice they have for others.
Source: www.amgen.comCategories: General Medicine News, PayerTweet-
Explaining ANCA-associated #vasculitis to friends, family, & even doctors can be challenging due to its diverse & sometimes invisible manifestations. ➡️ Read Rodney's story to learn more about the importance of self-advocacy for a rare disease diagnosis: https://t.co/1EVitB5G6h https://t.co/Enoo6j9bgS
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Mashup Score: 2Taking on Vasculitis, Together: Meet Rodney and Debbie - 4 month(s) ago
To gain a deeper understanding of their journey with ANCA-associated vasculitis (AAV), Amgen recently sat down with Rodney and Debbie to hear their story and what advice they have for others.
Source: www.amgen.comCategories: General Medicine News, PayerTweet-
Explaining ANCA-associated #vasculitis to friends, family, & even doctors can be challenging due to its diverse & sometimes invisible manifestations. ➡️ Read Rodney's story to learn more about the importance of self-advocacy for a rare disease diagnosis: https://t.co/1lIxI1JOCZ https://t.co/2UPCTMzn76
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Mashup Score: 3Taking on Vasculitis, Together: Meet Rodney and Debbie - 4 month(s) ago
To gain a deeper understanding of their journey with ANCA-associated vasculitis (AAV), Amgen recently sat down with Rodney and Debbie to hear their story and what advice they have for others.
Source: www.amgen.comCategories: General Medicine News, PayerTweet-
Explaining ANCA-associated #vasculitis to friends, family, & even doctors can be challenging due to its diverse & sometimes invisible manifestations. ➡️ Read Rodney's story to learn more about the importance of self-advocacy for a rare disease diagnosis: https://t.co/Dg5b44IVzC https://t.co/a1dPQ1FeNH
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Mashup Score: 28Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying - 4 month(s) ago
Objectives This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic antibody-associated vasculitis (AAV) registries. Methods Through creation of the vasculitis-specific Findable, Accessible, Interoperable, Reusable, VASCulitis ontology, we harmonised the registries and enabled semantic interoperability. We assessed data quality across the domains of uniqueness, consistency, completeness and correctness. Aggregated data were retrieved using the semantic query language SPARQL Protocol and Resource Description Framework Query Language (SPARQL) and outcome rates were assessed through random effects meta-analysis. Results A total of 5282 cases of AAV were identified. Uniqueness and data-type consistency were 100% across all assessed variables. Completeness and correctness varied from 49%–100% to 60%–100%, respectively. There were 2754 (52.1%)
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 0Relapse Risk and Safety of Long-Term Tocilizumab Use Among Patients With Giant Cell Arteritis: A Single-Enterprise Cohort Study - 5 month(s) ago
Objective To evaluate the safety and efficacy of tocilizumab (TCZ) in giant cell arteritis (GCA) in a large North American cohort. Methods Patients with GCA treated with TCZ between January 1, 2010, and May 15, 2020, were retrospectively identified. Kaplan-Meier methods were used to estimate time to TCZ discontinuation and time to first relapse after TCZ discontinuation. Poisson regression models were used to compare annualized relapse rates before, during, and after TCZ use. Age- and sex-adjusted risk factors associated with relapse on and off TCZ and development of adverse events of significant interest (AESIs) were examined using Cox models. Results One hundred fourteen patients (60.5% female) were included with mean (SD) age 70.4 (8.2) years. Median duration from GCA diagnosis to TCZ start was 4.5 months. Median overall duration of TCZ treatment was 2.3 years. Relapse rate prior to TCZ start (0.84 relapses/person-year) was 3-fold reduced while on TCZ (0.28 relapses/person-year; P <
Source: www.jrheum.orgCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 7
Bywaters lesion is a cutaneous vasculitis seen in rheumatoid arthritis.1 A 70-year-old man presenting with polyarthritis and finger papules visited our hospital. The patient had a 12-year history of polyarthritis, and bilateral ulnar deviation developed 5 years prior. Computed tomography indicated interstitial pneumonia, and blood work confirmed a rheumatoid factor level of 2708 (normal < 15) IU/mL and anticyclic citrullinated peptide antibody …
Source: www.jrheum.orgCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 2Temporal Artery Ultrasound for the Diagnosis of Giant Cell Arteritis in the Emergency Department - 7 month(s) ago
Giant cell arteritis (GCA), known as temporal arteritis, is a serious condition requiring immediate treatment to prevent complications. GCA can be difficult to diagnose, especially in emergency department (ED) settings where ophthalmology and rheumatology …
Source: www.ncbi.nlm.nih.govCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
Objective To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods Patients with a definite diagnosis of AAV who were followed for ≥ 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) a
Source: www.jrheum.orgCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0For Your Eyes Only: 007 Tips for the Management of Cardiovascular Risk Factors in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis - 7 month(s) ago
Premature atherosclerosis has been observed during the course of different systemic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).1-3 As a result, cardiovascular (CV) events, including myocardial infarction, stroke, heart failure, coronary artery disease, and death, occur 1.65 to 3 times more commonly in patients with AAV as compared to the general population, and the risk appears to be highest in the first year following diagnosis.3 After the first year, however, CV disease (CVD) remains the most important cause of death besides malignancy and infection. It has been demonstrated that traditional risk factors for CVD, such as hypertension, dyslipidemia, diabetes, age, and a family history of CVD, are highly prevalent in AAV. In this issue of The Journal of Rheumatology , Moiseev et al demonstrated that smoking and pulmonary involvement were also associated with an increa
Source: www.jrheum.orgCategories: Latest Headlines, RheumatologyTweet
Explaining ANCA-associated #vasculitis to friends, family, & even doctors can be challenging due to its diverse & sometimes invisible manifestations. ➡️ Read Rodney's story to learn more about the importance of self-advocacy for a rare disease diagnosis: https://t.co/Av2V1qNwMx https://t.co/uSIUyl20Hv