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Mashup Score: 16DNA vaccine against Zika performs well in tests on mice - 2 day(s) ago
In Brazil, researchers at the University of SĂŁo Paulo (USP) and the Pernambuco division of Oswaldo Cruz Foundation (FIOCRUZ) are developing a Zika vaccine. The formulation was tested on mice and …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity - 2 month(s) ago
Nature Communications – Many viral infections are linked to the development of neurological disorders. Here, Balint et al use a mouse model of Zika virus infection to show that it is immune cells…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 20Brazilian study indicates Zika reinfection possible - 3 month(s) ago
Because Zika often does not require medical care, many reinfections may have gone unnoticed, the study authors say.
Source: www.cidrap.umn.eduCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 20Brazilian study indicates Zika reinfection possible - 3 month(s) ago
Because Zika often does not require medical care, many reinfections may have gone unnoticed, the study authors say.
Source: www.cidrap.umn.eduCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 28Dual function of Zika virus NS2B-NS3 protease - 4 month(s) ago
Author summary Zika virus (ZIKV) serine protease is indispensable for viral replication and is composed of the proteas and helicase subunits. We discovered that the ZIKV protease subunit binds RNA, suggesting a novel function. We tested various structural modifications and conformations of ZIKV protease and observed that only one of three possible conformations, the “open” proteolytically inactive conformation, binds RNA. We identified specific 3-dimensional structures present only in the open conformation of many flaviviruses, including ZIKV and Dengue, suggesting that our finding may have a broad implication for several flaviviruses. We propose a novel “reverse inchworm” model for helicase-protease machinery that is key for viral propagation and possible novel ways of targeting flaviviruses.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1Potential Range of Aedes Mosquitoes in US | CDC - 10 month(s) ago
Maps for Aedes aegypti and Aedes albopictus mosquitoes showing their potential range in the continental US.
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 13
Author summary Rising temperatures through climate change are expected to increase arboviral disease pressure, so understanding the impact of climate change on newly emerging diseases such as Zika is essential to prepare for future outbreaks. However, because disease transmission may be less effective at very high temperatures, it is uncertain whether risk will uniformly increase in different…
Source: journals.plos.orgCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation - Nature Communications - 12 month(s) ago
Zika virus poses a potential threat to male reproductive health but the underlying mechanisms remain obscure. To address this question, the study by Yang et al performs single-cell RNA sequencing with ZIKV-infected mice testes. The authors find that spermatogenic cells are fragile to ZIKV infection and the complement system components produced by infiltrated S100A4 + monocytes/macrophages are…
Source: NatureCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 1Dengue, zika, chikungunya : il faut s'y préparer en métropole - 1 year(s) ago
Le Covars a rendu un avis sur ces maladies tropicales qui, à la faveur de la propagation du moustique tigre en métropole, vont indéniablement se multiplier sur le territoire. Les médecins doivent savoir en reconnaitre les symptômes.
Source: MedscapeCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 7Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1 - Nature Communications - 1 year(s) ago
Human RNA binding protein Musashi-1 binds various host transcripts as well as Zika virus RNA in neural progenitor cells. Here, Chen et al. characterise the interactions between Musashi-1 and its binding site using a combination of molecular and biophysical methods to shed light on its role in viral neurotropism.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
DNA vaccine against #Zika performs well in tests on mice @frontiersin https://t.co/3LTa6yItVJ