Deciphering the impact of metabolic intervention on response to anticancer therapy may elucidate a path toward improved clinical responses. Here, we identify amino acid-related pathways connected to the folate cycle whose activation predicts sensitivity to MYC-targeting therapies in acute myeloid leukemia (AML). We establish that folate restriction and deficiency of the rate-limiting folate cycle…
The initial Hallmarks of Cancer were first described in 2000 by Douglas Hanahan and Robert Weinberg as a set of six essential functional properties of…
Read the paper here: https://doi.org/10.1158/2159-8290.CD-24-0139
Summary:. Cancer Grand Challenges is an international funding initiative that aims to unite the world’s best scientists to tackle some of cancer’s toughest problems by…
Summary:. The NCI director presents her vision of the National Cancer Plan as an integrated framework that can help drive innovation in cancer research to…
Summary:. The Biden Cancer Moonshot is mobilizing efforts toward achieving two clear goals that President Joe Biden and First Lady Jill Biden set: prevent more…
Read the paper here: https://doi.org/10.1158/2159-8290.CD-24-0217
In last year’s editorial (1), we reiterated that the central mission of Cancer Discovery is to bring together basic, translational, and clinical cancer researchers to…
Read the paper: https://doi.org/10.1158/2159-8290.CD-24-0102
This week: Tidbits from the American Association for Cancer Research (AACR) Annual Meeting, held April 5–10, in San Diego, CA, and other news. Soon, there…
Abstract: Researchers have successfully developed a liquid biopsy ovarian cancer assay. Known as DELPHI-protein, the assay uses AI to cross reference the presence of cell-free…
