Oliver et al. comprehensively review the anatomy, development, and functional roles of the lymphatic vasculature in health and disease. They highlight emerging evidence suggesting that the lymphatic system plays more diverse physiological roles that previously appreciated.
IGSF8, aberrantly expressed on malignant cells, functions as an innate immune checkpoint that inhibits cytotoxicity of natural killer cells. A monoclonal antibody targeting IGSF8 alone,…
The molecular mechanisms regulating stem cell niche formation are poorly understood. Here, an epitranscriptomic program relying on Mettl3 is uncovered that is distinctly important for…
Naturally inspired protein engineering produces synpoptosis circuits that programmably control user-selectable death programs in target mammalian cells.
(Cell 186, 147–161.e1–15; January 5, 2023)
Zong et al. identified the tumor-derived L-lactate as a natural suppressor of p53 and screened out AARS1 as an intracellular L-lactate sensor and lactyl-transferase that mediates…
The microbial bile acid 3-succinylated cholic acid is biosynthesized by BAS-suc, an enzyme annotated as β-lactamase in Bacteroides uniformis, and it alleviates MASH progression by…
Brown fat contributes to systemic glucose homeostasis by providing BCAA-nitrogen-derived metabolites, including glutathione, to the liver, a function that is distinct from the well-known role…
Spatial mapping shows that glioblastoma consists of both disorganized and structured regions. Structured regions display a five-layered organization that is associated with hypoxia and extends…
DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.
SARS-CoV-2 uses ORF6, a conserved protein among sarbecoviruses, to evade cytotoxic cell NKG2D recognition through a mechanism that results in the shedding of the surface…
