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Mashup Score: 22What Can 11,000 Proteins In Our Blood Tell Us? - 2 hour(s) ago
The beginnings of a quiet revolution in high-throughput proteomics and A.I.
Source: erictopol.substack.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 22What Can 11,000 Proteins In Our Blood Tell Us? - 3 hour(s) ago
The beginnings of a quiet revolution in high-throughput proteomics and A.I.
Source: erictopol.substack.comCategories: General Medicine News, Expert PicksTweet-
Two proteomic studies have found peaks of plasma proteins at different ages, which suggests that the aging process is non-linear Links and details https://t.co/J8wio9Sqgm https://t.co/NGkVO98odB
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Mashup Score: 139Opinion | I’m a Doctor. ChatGPT’s Bedside Manner Is Better Than Mine. (Gift Article) - 23 hour(s) ago
My job is no longer safe.
Source: www.nytimes.comCategories: General Medicine News, Expert PicksTweet-
In medicine, #ChatGPT and other LLMs have surprisingly and consistently been shown to promote empathy better than physicians "You might find it disturbing that A.I. can have a better bedside manner than humans."—@jonreismanMD @nytopinion Gift link https://t.co/byXWfvhlu1
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Mashup Score: 387Impact of JN.1 booster vaccination on neutralisation of SARS-CoV-2 variants KP.3.1.1 and XEC - 1 day(s) ago
The SARS-CoV-2 KP.3.1.1 lineage is currently the dominating lineage on several continents. In parallel, the XEC lineage, a recombinant of KS.1.1 and KP.3.3, is on track of becoming the next dominant lineage in Europe and North America. Here we performed a rapid virological characterisation of the XEC lineage and studied the impact of JN.1 mRNA booster vaccination on KP.3.1.1 and XEC neutralisation. ### Competing Interest Statement A.K., I.N., S.P. and M.H. conducted contract research (testing of vaccinee sera for neutralising activity against SARS-CoV-2) for Valneva unrelated to this work. G.M.N.B. served as advisor for Moderna and S.P. served as advisor for BioNTech, unrelated to this work. A.D-J. served as advisor for Pfizer, unrelated to this work. All other authors declare no competing interests.
Source: www.biorxiv.orgCategories: General Medicine News, Expert PicksTweet-
First lab characterization of the effect of vaccination (JN.1-spike directed) on the emerging XEC variant https://t.co/2udQ8AgAPn @inflammationHL Drop-off of neutralization response compared with KP.3.1.1 (current dominant variant) but should still be protective https://t.co/9raXN1509j
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Mashup Score: 4778
PICOBOO is a randomised, adaptive trial evaluating the immunogenicity, reactogenicity, and safety of COVID-19 booster strategies. We report data for second boosters among individuals 50-<70 years old primed with AZD1222 (50-<70y-AZD1222) until Day 84.
Source: www.journalofinfection.comCategories: General Medicine News, Expert PicksTweet-
From a randomized trial, proof that the @Novavax booster induces less acute side effects and more sustained levels of anti-spike IgG antibodies than mRNA shots @moderna_tx @pfizer https://t.co/dl2TkyyjaU Right panel represents anti-spike IgG unadjusted fold reductions at… https://t.co/S9LOz7ISRQ https://t.co/LfxToMnJVo
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Mashup Score: 1451
Nature – The treatment’s success in three people raises hopes for mass production of cutting-edge CAR T therapies.
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet-
It's exciting that we are now seeing multiple different groundbreaking interventions towards curing autoimmune diseases. Here's one path https://t.co/4GfoTnYsKR @Nature
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Mashup Score: 3399
These results support larger cross sectional findings indicating that mild Wildtype SARS-CoV-2 infection can be followed by small changes in cognition and memory that persist for at least a year. The mechanistic basis and clinical implications of these small changes remain unclear.
Source: www.thelancet.comCategories: General Medicine News, Expert PicksTweet-
With mild infection in healthy participants who received a #SARSCoV2 challenge there was evidence of persistent cognitive and memory changes at least one year after Covid, compared with uninfected controls https://t.co/HpPLn0peuJ @ProfHampshire @eClinicalMed https://t.co/sgiu47PXjL
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Mashup Score: 1451
Nature – The treatment’s success in three people raises hopes for mass production of cutting-edge CAR T therapies.
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet-
It's exciting that we are now seeing multiple different groundbreaking interventions towards curing autoimmune diseases. Here's one path https://t.co/4GfoTnYsKR @Nature
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Mashup Score: 1492
Nature Medicine – Using ethnically and geographically diverse metagenomic data, the authors identify microbiota alterations associated with inflammatory bowel disease (IBD). They discover universal…
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet-
Until now, the gut microbiome hasn't been used to make clinical diagnoses. That may change. A new report on its utility for non-invasively diagnosing inflammatory bowel disease. https://t.co/3R378buA8K @NatureMedicine @Siew_C_Ng https://t.co/A5bfWbDNhF
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Mashup Score: 376
A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.
Source: www.cell.comCategories: General Medicine News, Expert PicksTweet-
There's keen interest in getting rid of senescent cells in the body to slow the aging process. One little problem: there are many types of these cells, some are quite beneficial, essential for repair or regeneration https://t.co/jNHEJHzeJa @CellCellPress https://t.co/1H2hBoBey8 https://t.co/nt6pjPA3Xy
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Two proteomic studies have found peaks of plasma proteins at different ages, which suggests that the aging process is non-linear Links and details https://t.co/J8wio9Sqgm https://t.co/NGkVO98odB