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Mashup Score: 0
Autoimmune rheumatic diseases (AIRDs) are diseases with complex outset and courses, in which both genetic and environmental factors participate. Many environmental factors can be committed to AIRDs outset and development. The most popular of them, with confirmed impact, are smoking, age, gender, and microorganisms. In light of recent research an assumption about the importance of various microorganisms in the pathogenesis of AIRDs is growing in popularity.The human immune system has various protective mechanisms against infectious antigens which in normal cases let organism manage potential infection faster and more effectively.
Source: www.translationalres.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 0Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents - 3 day(s) ago
SARS-CoV-2 3CL protease (Main protease) and human cathepsin L are proteases that play unique roles in the infection of human cells by SARS-CoV-2, the causative agent of COVID-19. Both proteases recognize leucine and other hydrophobic amino acids at the P2 position of a peptidomimetic inhibitor. At the P1 position, cathepsin L accepts many amino acid side chains, with a partial preference for phenylalanine, while 3CL-PR protease has a stringent specificity for glutamine or glutamine analogues. We have designed, synthesized, and evaluated peptidomimetic aldehyde dual-target (dual-acting) inhibitors using two peptide scaffolds based on those of two Pfizer 3CL-PR inhibitors, Nirmatrelvir, and PF-835321. Our inhibitors contain glutamine isosteres at the P1 position, including 2-pyridon-3-yl-alanine, 3-pyridinyl-alanine, and 1,3-oxazo-4-yl-alanine groups. Inhibition constants for these new inhibitors ranged from Ki = 0.6β18 nM (cathepsin L) and Ki = 2.6β124 nM (3CL-PR), for which inhibitors
Source: pubs.acs.orgCategories: General Medicine News, Infectious DiseaseTweet-
π§ͺ Dr. Thomas Meek's lab at @TAMU demonstrated the value of a second generation of cysteine protease inhibitors that comprised a single agent that acted on both human cathepsin L and #SARSCoV2 3CL protease. π @J_A_C_S | https://t.co/IiPXF6EfWw https://t.co/huZKxEpRjA
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Mashup Score: 0Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID - 3 day(s) ago
Mukherjee et al. report that vaccination prior to SARS-CoV-2 infection does not affect the neurological manifestations of Long COVID. Minor symptom differe
Source: academic.oup.comCategories: General Medicine News, Infectious DiseaseTweet-
π Researchers investigated whether #vaccination prior to #infection altered the subsequent neurologic post-acute sequelae of #SARSCoV2 infection. π Check out the article at @braincomms! https://t.co/EzW9iA9uFD Press Release:ποΈ https://t.co/5HaktRSYUD https://t.co/liGbISHWlt
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Mashup Score: 0
Nature Microbiology – Systematic comparison of SARS-CoV-2 spike proteins from pre- and post-Omicron variants in cell lines, primary respiratory epithelial cells and Syrian hamsters show distinct…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet-
π· Giuditta De Lorenzo (@serdelor), Vanessa Cowton, Wilhelm Furnon (@WFurnon), and team members at @CVRinfo generated a panel of recombinant viruses carrying different spike proteins from 27 variants circulating between 2020 and 2024. π https://t.co/ntw7nySN6n https://t.co/miPGKJYbgw
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Mashup Score: 3
The swine industry annually suffers significant economic losses caused by porcine reproductive and respiratory syndrome virus (PRRSV). Because the available commercial vaccines have limited protective efficacy against epidemic PRRSV, there is an urgent need for innovative solutions. Nanoparticle vaccines induce robust immune responses and have become a promising direction in vaccine development. In this study, we designed and produced a self-assembling nanoparticle vaccine derived from thermophilic archaeal ferritin to combat epidemic PRRSV. First, multiple T cell epitopes targeting viral structural proteins were identified by IFN-Ξ³ screening after PRRSV infection. Three different self-assembled nanoparticles with epitopes targeting viral GP3, GP4, and GP5 proteins were constructed and mixed to generate a FeCocktail vaccine. Experiments showed that the FeCocktail vaccine effectively activated CD4+ and CD8+ T cells and effector memory T cells in mice. Piglets immunized with the FeCockta
Source: pubs.acs.orgCategories: General Medicine News, Infectious DiseaseTweet-
π Researchers designed and produced a self-assembling nanoparticle #vaccine derived from thermophilic archaeal ferritin to combat epidemic porcine reproductive and respiratory syndrome virus. #RSV π @acsnano | https://t.co/dxe7q0JM2M https://t.co/auI46OKDqx
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Mashup Score: 2Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stemβspecific human B cells - 10 day(s) ago
Vaccination with different group 2 influenza subtypes alters the balance of the human B cell response toward two supersites on the influenza stem.
Source: www.science.orgCategories: General Medicine News, Infectious DiseaseTweet-
π Scientists at @NIAIDNews characterized the stem-specific repertoire of individuals vaccinated with one of three group 2 #influenza subtypes. π @ScienceTM | https://t.co/hs976pcD5n https://t.co/9b7aqp4GsM
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Mashup Score: 0Incidence and outcome of hepatitis D virus infection in people with HIV in the era of tenofovir-containing antiretroviral therapy - 10 day(s) ago
HDV superinfection continues to occur among PWH in the era of tenofovir-containing antiretroviral therapy, which is associated with injection drug use and
Source: academic.oup.comCategories: General Medicine News, Infectious DiseaseTweet-
π Researchers investigated the incidence of #hepatitis D virus infection and its clinical impact in hepatitis B virus-coinfected people with #HIV in the era of tenofovir-containing #antiretroviral therapy. π @CIDJournal | https://t.co/1s4ffe274k https://t.co/gHpTQTkEEv
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Mashup Score: 1Polycytotoxic T cells mediate antimicrobial activity against intracellular Mycobacterium tuberculosis | Infection and Immunity - 29 day(s) ago
To establish active infection, inhaled Mycobacterium tuberculosis (Mtb) must overcome the physical barriers of the upper respiratory tract and invade alveolar macrophages. Clearance of the pathogen from the lower airways requires a fine-tuned interaction of immune cells, most prominently T-lymphocytes and macrophages. There is definite evidence for the critical role of CD4+ T-lymphocytes in activating the antimicrobial activity of macrophages (1). The evidence for a contribution of CD8+ T cells in protection against Mtb is steadily increasing through conclusive animal studies and strong circumstantial evidence from human ex vivo and in vitro experiments (2β7). CD8+ T-lymphocytes promote the control of Mtb infection indirectly by the release of macrophage-activating cytokines or directly by the injection of cytotoxic molecules into infected macrophages (8). The granular molecules perforin, granzyme B, and granulysin interact to define an antimicrobial effector pathway leading to direct
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
π« Investigators functionally characterized human NKG2A and NKG2C-expressing T cells using the major #pathogen Mycobacterium #tuberculosis as a model organism. π https://t.co/ZUjYkNeYgV https://t.co/zlmJAeYpDp
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Mashup Score: 1Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses - 1 month(s) ago
Hepatology International – The pivotal role of antibody-producing B cells in controlling hepatitis B virus (HBV) infection is well-established. However, the antiviral role of B cells extends beyond…
Source: link.springer.comCategories: General Medicine News, Infectious DiseaseTweet-
π Using a hepatitis B #virus (HBV) hydrodynamic injection, a mouse model with B cell depletion or functional blockade, researchers detected HBV #infection markers and assessed T cell function. π @hepinternation1 | https://t.co/DeQ3TaqrY7 https://t.co/P8qi2BwSGx
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Mashup Score: 0Single-cell immune profiling and validation of PBMCs in the onset of and recovery from herpes zoster - 1 month(s) ago
Communications Biology – Single-cell RNA-seq analysis integrated with ATAC-seq analysis of peripheral blood mononuclear cells demonstrates detailed immune cell profile in the onset of and recovery…
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet-
π©Ί Researchers provided deep insight into the #immune profile during #herpes zoster progression. π @CommsBio | https://t.co/AqoQ7tb5dL https://t.co/bnKke4mlIh
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π Check out this review by Drs. Ewa Bryl and Aleksandra Korzeniowska to learn all about the role of #viruses in the outset and development of #autoimmune rheumatic diseases! π https://t.co/gcgxdM522V https://t.co/QrPmjY8dvI