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Mashup Score: 27Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow - 18 hour(s) ago
Abstract. Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterizatio
Source: academic.oup.comCategories: General Medicine NewsTweet
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Mashup Score: 5Single-cell analysis of pig lung leukocytes and their response to influenza infection and oseltamivir therapy - 21 hour(s) ago
Abstract. Despite pigs being an important species in influenza A virus (IAV) epidemiology and a reliable preclinical model for human IAV infections, many a
Source: academic.oup.comCategories: General Medicine NewsTweet-
Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: https://t.co/5oMJCg4KEm https://t.co/QWFqHrYyIv
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Mashup Score: 2Decoding autoimmunity: HLA-DQβ and type 1 diabetes - 1 day(s) ago
This Pillars of Immunology article features the seminal 1987 Nature paper by J.A. Todd, J.I. Bell, and H.O. McDevitt, titled “HLA-DQβ gene contributes to s
Source: academic.oup.comCategories: General Medicine NewsTweet-
May’s Pillars of Immunology article highlights the seminal 1987 Nature paper by J.A. Todd, J.I. Bell, and H.O. McDevitt, which provided a breakthrough in understanding genetic susceptibility to type 1 #diabetes. Read the full commentary in The JI: https://t.co/Oum9MWO9Ge. https://t.co/2al1cKBiKz
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Mashup Score: 16Aging’s impact on the immune system - 2 day(s) ago
An onslaught of infectious disease events over the last 5 yr has focused international attention on immune aging. Specifically, how does the immune system
Source: academic.oup.comCategories: General Medicine NewsTweet-
A special collection on #aging and the immune system highlights the expanding field of immune aging, featuring an invited commentary from a pioneer in the field and a collection of 5 brief reviews from leaders in aging research. Read the editorial: https://t.co/eJzrfhueFP. https://t.co/nbOzWGee44
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Mashup Score: 27Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow - 2 day(s) ago
Abstract. Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterizatio
Source: academic.oup.comCategories: General Medicine NewsTweet-
Researchers have found evidence that S100A10 is critical for monocyte mobilization, suggesting that targeting the S100A10-CCR2 pathway may be an attractive approach to regulate inflammatory responses and infectious diseases. Read about it in The JI: https://t.co/i89OqKi3wi. https://t.co/mwWsBua8zT
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Mashup Score: 12Transcriptional and chromatin accessibility landscapes of hematopoiesis in a mouse model of breast cancer - 3 day(s) ago
Abstract. Increased myeloid lineage production, termed myeloid skewing, leading to decreased tumor immunity, is a hallmark of aberrant hematopoiesis associ
Source: academic.oup.comCategories: General Medicine NewsTweet-
Researchers characterized the transcriptional and chromatin accessibility landscapes of bone marrow and splenic hematopoietic progenitors in breast cancer to understand the hematopoietic consequences of cancer. Read more: https://t.co/2T2MeU4IPa. https://t.co/hBANhasbSZ
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Mashup Score: 24ICOS+ CD4+ T cells promote antitumor immunity through Akt/STAT1/T-bet axis in MSS/pMMR colorectal cancer - 4 day(s) ago
Abstract. Inducible Co-Stimulator (ICOS), as a T-cell–specific costimulatory receptor that enhances T-cell responses to foreign antigens, plays a crucial r
Source: academic.oup.comCategories: General Medicine NewsTweet-
Data revealed that inducible co-stimulator (ICOS) mediates antitumor immunity by promoting the secretion of cancer-suppressive cytokines, suggesting that activation of ICOS may be a potential therapeutic strategy for #colorectalcancer. Read more: https://t.co/gFW9s6d7ON. https://t.co/Erl6sEj2mR
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Mashup Score: 6Sustained activation induced cytidine deaminase (AID) expression in B cells following Plasmodium falciparum malaria infection in Kenyan children - 21 day(s) ago
Abstract. Burkitt lymphoma (BL) is characterized by elevated levels of the enzyme activation-induced cytidine deaminase (AID), an enzyme critical for MYC t
Source: academic.oup.comCategories: General Medicine NewsTweet-
#ICYMI: Data suggest that P. falciparum #malaria and Epstein-Barr virus coinfection result in sustained expression of activation-induced cytidine deaminase (AID), influencing the MYC translocation that is characteristic of Burkitt #Lymphoma. Read more: https://t.co/FlI7Cv27M5 https://t.co/zgvA0TTcXJ
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Mashup Score: 3Bcl-xL is important for the antiapoptotic activity of Gfi1 and is upregulated by Gfi1 through hemgn - 22 day(s) ago
Abstract. Gfi1 is a transcriptional repressor that plays a critical role in hematopoiesis. Gfi1 represses its target genes primarily through interacting wi
Source: academic.oup.comCategories: General Medicine NewsTweet-
Data reveals a novel mechanism by which Gfi1 inhibits apoptosis. Researchers found that upregulation of Bcl-xL by Gfi1 was dependent on Hemgn upregulation, which resulted from Gfi1-mediated repression of PU.1. Learn more: https://t.co/05Ym88KC2I https://t.co/gElZO4KFxr
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Mashup Score: 14Accurate enumeration of pathogen-specific and virtual memory CD8 T cells after infection - 23 day(s) ago
Abstract. Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for
Source: academic.oup.comCategories: General Medicine NewsTweet-
Data shows that defining the magnitude and kinetics of an Ag-specific CD8 T-cell response requires distinguishing pathogen-induced effector and memory CD8 T cells from Tvm cells to improve the resolution of studies understanding CD8 T cells. Read more: https://t.co/V2EbMJKhem. https://t.co/AC9m3NgLU0
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Researchers have found evidence that S100A10 is critical for monocyte mobilization, suggesting that targeting the S100A10-CCR2 pathway may be an attractive approach to regulate inflammatory responses and infectious diseases. Read about it in The JI: https://t.co/i89OqKi3wi. https://t.co/mwWsBua8zT