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Mashup Score: 352The Epigenetic Hallmarks of Cancer - 2 day(s) ago
Abstract. Cancer is a complex disease in which several molecular and cellular pathways converge to foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks, “nonmutational epigenetic reprogramming” was newly added. However, epigenetics, much like genetics, is a broad scientific area that deserves further attention due to its multiple roles in cancer initiation, progression, and adaptive nature. Herein, we present a detailed examination of the epigenetic hallmarks affected in human cancer, elucidating the pathways and genes involved, and dissecting the disrupted landscapes for DNA methylation, histone modifications, and chromatin architecture that define the disease.Significance: Cancer is a disease characterized by constant evolution, spanning from its initial premalignant stages to the advanced invasive and disseminated stages. It is a pathology that is able to adapt and survive amidst hostile cellular microenvironments and diverse treatments implemented
Source: aacrjournals.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 14Invited lectures - 3 day(s) ago
Josep Carreras Leukaemia Research Institute Events related to activity Invited Lectures
Source: www.carrerasresearch.orgCategories: General Medicine News, Future of MedicineTweet-
Do not miss today at 12.00h our Invited @CarrerasIJC Lecture by Dr Pere Barba @pebarba from @VHIO @hemato_vhebron @UABBarcelona explaining how to improve #patient outcome upon CAR T-cell therapy #immunology #immunotherapy https://t.co/WGZNhZOyFA https://t.co/7DK9oUmvnO
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Mashup Score: 7Descriuen per què els tumors evolucionen i són immortals - 5 day(s) ago
Investigadors identifiquen les característiques genètiques que comparteixen tots els càncers
Source: www.ara.catCategories: General Medicine News, Future of MedicineTweet-
https://t.co/nhZLCgmdgq
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Mashup Score: 9
La Núria Martínez ha anat a conèixer la persona més gran de Catalunya, Angelina Torres, i hem parlat de longevitat amb el doctor Manel Esteller.
Source: www.ccma.catCategories: General Medicine News, Future of MedicineTweet-
https://t.co/yqo9PwLV1T https://t.co/m5AAxmXGUN
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Mashup Score: 17Actualidad bio salud euskadi - Basque Health Cluster - 12 day(s) ago
#taglineasociación del sector de las biociencias y la saludEl acto de entrega tuvo lugar el pasado lunes 16 de septiembre en el auditorio del Instituto de Investigación contra la Leucemia Josep Carreras de Badalona. El galardón distingue el trabajo del Dr. Manel Esteller, Doctor en Medicina y Cirugía por la Universidad de Barcelona, y reconocido por el jurado del XXI Premio de
Source: basquehealthcluster.orgCategories: General Medicine News, Future of MedicineTweet-
El Dr. Manel Esteller Badosa recibe el XXI Premio de Investigación Burdinola BASQUE HEALTH CLUSTER https://t.co/HFyRNBXhZE https://t.co/PHiTwdhPUh
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Mashup Score: 17
Nature Communications – This study suggests a mechanism by which LSD1 controls DNA methylation in mouse ESCs, independently of its lysine demethylase activity. The demethylase-independent function…
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Contributing to @NatureComms exciting story led by @mal71056 and @Xisca_Aguilo @umeauniversity @WCMM_UmU showing how #histone #demethylase LSD1 regulates DNA #methylation in #embryonic stem cells https://t.co/wgxDGUeD0Z https://t.co/zSxaXU0qbf
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Mashup Score: 11
Maintenance of pluripotency is a multifactorial process in which NF-κB is a negative regulator. Our previous work identified a chromatin role for IκBα, the master regulator of NF-κB signaling, that is critical for the proper regulation of various tissue stem cells. Here, we found that IκBα accumulates specifically in the chromatin fraction of pluripotent embryonic stem cells. IκBα depletion does not affect NF-kB-dependent transcription, but causes a profound epigenetic rewiring in pluripotent stem cells, including alterations in H3K27me3, a histone mark catalyzed by Polycomb repression complex 2. Chromatin changes induced by IκBα depletion affect a subset of pluripotency genes and are associated with altered gene transcription. At the cellular level, IκBα-deficient embryonic stem cells are arrested in a naive pluripotency state when cultured in serum/LIF conditions and fail to exit pluripotency under differentiation conditions. By constructing separation-of-function mutants, we show th
Source: www.biorxiv.orgCategories: General Medicine News, Future of MedicineTweet-
Contributing to @biorxivpreprint beautiful story by @luis1odin @BigSpinLab showing how #chromatin changes induced by IκBα, such as #Polycomb H3K27me3 #histone mark, regulate #stem cell #pluripotency and #inflammation https://t.co/QsZSxf4ok0 https://t.co/RaKf9geMKX
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Mashup Score: 11Maria Branyas Morera, World’s Oldest Person, Dies at 117 - 2 month(s) ago
Ms. Morera, who cultivated a following on social media as “Super Catalan Grandma,” died peacefully in her sleep, her family said.
Source: www.nytimes.comCategories: General Medicine News, Future of MedicineTweet-
Contributing to New York Times @nytimes obituary of Maria Branyas Morera, oldest person in the world. Recognizing how supportive she was of our #aging #research and providing first glimpse of her amazing multiomics makeup. She will be deeply missed. https://t.co/YsEpqSoxbX https://t.co/UQJ9A3umFv
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Mashup Score: 16INSOLITE. À la recherche de la jeunesse perdue : la doyenne de l'humanité est catalane, des scientifiques étudient son ADN - 2 month(s) ago
Depuis l’année dernière, la doyenne de l’humanité est catalane. À Badalona, près de Barcelone, une équipe de chercheurs étudie son ADN pour tenter de percer les mystères de la longévité. Ils ont ouvert les portes de leur…
Source: france3-regions.francetvinfo.frCategories: General Medicine News, Future of MedicineTweet-
https://t.co/zCy0E8Ty77 @franceinfo https://t.co/DvaItCRCaC
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Mashup Score: 15Discovery and evaluation of novel biomarkers reveal dasatinib as a potential treatment for a specific subtype of Triple-Negative Breast Cancer - 2 month(s) ago
Triple-negative breast cancer (TNBC) represents the most heterogeneous and aggressive subtype of breast carcinomas, characterized by the absence of clinical biomarkers (ERα, PR, and HER2) and the lack of targeted therapies. In this regard, several clinical trials have consistently failed to effectively stratify patients and identify specific treatments that elicit substantial responses. This study aims to pinpoint biomarkers expressed exclusively in the basal mammary epithelial compartment, facilitating a refined subclassification of this breast cancer subtype. Using computational analyses of single-cell RNA sequencing data, we have identified a list of genes associated with basal identity (BC-markers). Histological validation in human samples has enabled us to categorize TNBC patients into BC-positive and BC-negative TNBC subtypes. Significantly, the presence of these markers correlates with a poorer prognosis in TNBC patients. Functional analyses have revealed a pivotal role for TAGL
Source: www.biorxiv.orgCategories: General Medicine News, Future of MedicineTweet-
Participating in nice discovery by @vrodillab at @CarrerasIJC of response biomarkers for tyrosine kinase inhibitor #dasatinib in triple-negative #breastcancer #TNBC, the most aggressive subtype; article available at @biorxivpreprint : https://t.co/ssKSUcHq2U https://t.co/ysnIOvtklS
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Thrilled to introduce "The Epigenetic Hallmarks of Cancer", our Cancer Discovery @CD_AACR @AACR article. A team work by Mark Dawson @MAF_Dawson, Cigall Kadoch @CKadoch, Feyruz Rassool, Peter Jones, Steve Baylin and yours truly. Enjoy! https://t.co/A51wTV9NUk https://t.co/Dex8sfJ2OP