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Mashup Score: 3
Abstract. Biliary tract cancers (BTCs) are a heterogeneous group of tumors arising from cells in the bile ducts and gallbladder. The 5-year overall surviva
Source: academic.oup.comCategories: General Medicine NewsTweet
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Mashup Score: 1The association of health care contact days with economic measures in the CCTG LY.12 trial - 2 day(s) ago
AbstractBackground. Given the intensive resources required to conduct economic analyses in clinical trials, a key need is identifying scalable measures of
Source: academic.oup.comCategories: General Medicine NewsTweet-
Dr @guptaarjun90 et al show contact days—days w/ healthcare contact—correlate w/ both #direct & #indirectcosts in lymphoma trials #fintox. They may be a scalable proxy for health system costs but don't fully capture #patient and #caregiver burden #supponc https://t.co/OQhajpxZEg https://t.co/3BXYZBVdfa
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Mashup Score: 5
AbstractBackground. Trifluridine-tipiracil (TAS-102) is approved as monotherapy and in combination with bevacizumab for refractory unresectable metastatic
Source: academic.oup.comCategories: General Medicine NewsTweet-
Dr @ChrisCannMD & team show biweekly TAS-102 #BiTS in #crcsm ⬇️grade ≥3 neutropenia & anemia and maintained similar #PFS (4.2mo) & #OS (9.2mo) vs standard dosing. This schedule may improve tolerability & support combination 💊💉#Bev #GIonc https://t.co/JPw4Pl0gTR https://t.co/YvtcLChH2F
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Mashup Score: 0A phase 0, window of opportunity study of parasympathetic stimulation with bethanechol in localized pancreatic adenocarcinoma prior to surgery - 21 day(s) ago
AbstractBackground. The parasympathetic branch of the autonomic nervous system has shown tumor-suppressive effects in preclinical models of pancreatic aden
Source: academic.oup.comCategories: General Medicine NewsTweet-
In this Phase 0 study, #bethanechol was well tolerated in resectable #pancsm and showed #antiinflammatoryeffects, including ⬇️IL-18 and Granzyme B+ cells. These findings support further study of #parasympatheticmodulation #GIonc @susanebates https://t.co/eXwuR9yRUW https://t.co/2JV2xLQMod
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Mashup Score: 6
AbstractBackground. FGFR alterations are known to be driver alterations in several tumor types. We aimed to assess the efficacy of pemigatinib, an oral FGF
Source: academic.oup.comCategories: General Medicine NewsTweet-
'@MargaretWheless et al show that Pemigatinib 🎯showed no #ORR n FGF/FGFR-altered #crcsm. Most had mutations/amplifications, not fusions #GIonc @KristenCiombor @GIcancerDoc https://t.co/fC8xmMIB72 https://t.co/hdim0wRDtO
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Mashup Score: 0Incidence of patient-reported fatigue developing on palbociclib and endocrine therapy for advanced HR+ HER2− breast cancer - 25 day(s) ago
AbstractObjectives. Fatigue is a common nonhematologic toxicity of the CDK4/6 inhibitor palbociclib in metastatic breast cancer (MBC) patients with prevale
Source: academic.oup.comCategories: General Medicine NewsTweet-
Palbociclib & endocrine therapy for metastatic breast cancer can increase life expectancy but also increases fatigue, possibly lowering QoL. Biological markers & behavioral factors may help identify at-risk populations & optimize treatment plans. https://t.co/X3qbCFjjfp https://t.co/54CooMB9Z3
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Mashup Score: 7Anthracyclines-induced cardiotoxicity in patients with early breast cancer carrying germline BRCA1/2 mutation: the BRCAN study - 1 month(s) ago
AbstractBackground. BRCA1/2 genes play a critical role in genome stability and DNA repair. In animal models, loss of cardiomyocyte-specific BRCA1/2 is asso
Source: academic.oup.comCategories: General Medicine NewsTweet-
#BRCA 1/2 mutation carriers could represent a higher-risk population for anthracyclines-induced #cardiotoxicity in patients with HER2-negative early breast cancer. #CardioOnc #BreastCancer #CardioTwitter #BRCAN https://t.co/fc7CE1dVFR https://t.co/Ct7WaPAPXV
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Mashup Score: 5Breast cancer incidence and mortality, by age, stage and molecular subtypes, by race/ethnicity in Canada - 1 month(s) ago
This article focuses on whether breast cancer characteristics and outcomes differ by race and ethnicity in Canada.
Source: academic.oup.comCategories: General Medicine NewsTweet-
'@anwilkinson and @JeanSeely working with @StatCan_eng show women of racial and ethnic groups other than White are diagnosed with breast cancer at younger ages and more advanced stages. https://t.co/GApIwkoMAG https://t.co/6HQzF44HsR
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Mashup Score: 14The impact of immune-related adverse events on survival outcomes in a racially diverse population, with a focus on non-Hispanic Black patients - 1 month(s) ago
The development of immune-related adverse events (irAEs) has been associated with improved survival outcomes in non-small cell lung cancer (NSCLC). This st
Source: academic.oup.comCategories: General Medicine NewsTweet-
Study finds irAEs in NSCLC patients linked to better survival outcomes regardless of race. Insights into diverse patient responses crucial for personalized care. #NSCLC #immunotherapy #healthdisparities @amrradwan05 @Jani_Chinmay @umittapan_LC_MD https://t.co/S85E8IfHuR https://t.co/5DJ5UpQvuN
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Mashup Score: 2
This study focused on a prospective cost analysis conducted at a high-specialty health facility to assess the economic implications of implementing a risk-
Source: academic.oup.comCategories: General Medicine NewsTweet-
Risk-sharing agreement (RSA) study reveals that RSAs alleviate financial burden of immunotherapy, fostering a more sustainable healthcare model with up to 40% cost reduction. @ogarrieta https://t.co/odi4UejJ4w https://t.co/9CE0uRsjrt
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‘@kspencer725 and King bring a review of #MDM2 amplification as an emerging target 🎯 across #btcsm Therapies restoring p53 function via #MDM2inhibition show promise but remain investigational #GIonc https://t.co/U5xZTJl1Rj https://t.co/JO342bLms9