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Mashup Score: 1
)/Tween 80 (5%) or a water-based formulation before formalin flinching on day 1 and tactile thresholds assessed before and after APAP at day 12. (2) Paw incision. At 24 hours and 8 days after hind paw incision in male mice, effects of intraperitoneal APAP on tactile allodynia were assessed. (3) Repeated delivery. Mice received daily (4 days) analgesic doses of APAP or vehicle and tested upon formalin flinching on day 5. (4) Conditioned place preference. For 3 consecutive days, vehicle was given in the morning in either of 2 chambers and in each afternoon, an analgesic dose of morphine or APAP in the other chamber. On days 5 and 10, animals were allowed to select a “preferred” chamber. Results: Formalin in male mice resulted in biphasic flinching and an enduring postformalin tactile allodynia. Acetaminophen dose dependently decreased phase 2 flinching, and reversed allodynia was observed postflinching. At a comparable APAP dose, female mice showed similarly reduced phase 2 flinching. In
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 1
)/Tween 80 (5%) or a water-based formulation before formalin flinching on day 1 and tactile thresholds assessed before and after APAP at day 12. (2) Paw incision. At 24 hours and 8 days after hind paw incision in male mice, effects of intraperitoneal APAP on tactile allodynia were assessed. (3) Repeated delivery. Mice received daily (4 days) analgesic doses of APAP or vehicle and tested upon formalin flinching on day 5. (4) Conditioned place preference. For 3 consecutive days, vehicle was given in the morning in either of 2 chambers and in each afternoon, an analgesic dose of morphine or APAP in the other chamber. On days 5 and 10, animals were allowed to select a “preferred” chamber. Results: Formalin in male mice resulted in biphasic flinching and an enduring postformalin tactile allodynia. Acetaminophen dose dependently decreased phase 2 flinching, and reversed allodynia was observed postflinching. At a comparable APAP dose, female mice showed similarly reduced phase 2 flinching. In
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference” by @Yaksh_YakshLab et al. https://t.co/TC2UzNxdwP https://t.co/2vrgtSmZTB
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Mashup Score: 2
)/Tween 80 (5%) or a water-based formulation before formalin flinching on day 1 and tactile thresholds assessed before and after APAP at day 12. (2) Paw incision. At 24 hours and 8 days after hind paw incision in male mice, effects of intraperitoneal APAP on tactile allodynia were assessed. (3) Repeated delivery. Mice received daily (4 days) analgesic doses of APAP or vehicle and tested upon formalin flinching on day 5. (4) Conditioned place preference. For 3 consecutive days, vehicle was given in the morning in either of 2 chambers and in each afternoon, an analgesic dose of morphine or APAP in the other chamber. On days 5 and 10, animals were allowed to select a “preferred” chamber. Results: Formalin in male mice resulted in biphasic flinching and an enduring postformalin tactile allodynia. Acetaminophen dose dependently decreased phase 2 flinching, and reversed allodynia was observed postflinching. At a comparable APAP dose, female mice showed similarly reduced phase 2 flinching. In
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference” by @Yaksh_YakshLab et al. https://t.co/TC2UzNxdwP https://t.co/2vrgtSmZTB
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Mashup Score: 3
to provide insight into key elements of TSP stimulation and assessment: modality, instruments, test location, familiarization, train characteristics, and calculations. PubMed, Embase, and Ebsco/CINAHL were searched for studies that measured TSP in adults with musculoskeletal conditions and healthy people. Four hundred six studies were included. Mechanical stimuli were the most commonly used modality (250 studies), followed by thermal stimuli (125 studies). Forty-six different instruments were used. Disregarding studies on widespread musculoskeletal pain and healthy participants, 40 studies evaluated TSP at painful sites, 77 in remote areas, and 66 in both locations. Of the 13 tested locations in patients, the hand (74 studies), lower leg (64 studies), and forearm (59 studies) were most commonly tested. A single practice round was the most common familiarization method (46 studies). Repeated stimuli were applied using 31 different frequencies (0.03-200 Hz) and sustained stimulations ran
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “A myriad of methods to determine temporal summation of pain in people with musculoskeletal pain and healthy participants: a scoping review” by @sjoerdkielstra et al. https://t.co/Jhm3FA3fpU https://t.co/61SEFWR4O9
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Mashup Score: 3
to provide insight into key elements of TSP stimulation and assessment: modality, instruments, test location, familiarization, train characteristics, and calculations. PubMed, Embase, and Ebsco/CINAHL were searched for studies that measured TSP in adults with musculoskeletal conditions and healthy people. Four hundred six studies were included. Mechanical stimuli were the most commonly used modality (250 studies), followed by thermal stimuli (125 studies). Forty-six different instruments were used. Disregarding studies on widespread musculoskeletal pain and healthy participants, 40 studies evaluated TSP at painful sites, 77 in remote areas, and 66 in both locations. Of the 13 tested locations in patients, the hand (74 studies), lower leg (64 studies), and forearm (59 studies) were most commonly tested. A single practice round was the most common familiarization method (46 studies). Repeated stimuli were applied using 31 different frequencies (0.03-200 Hz) and sustained stimulations ran
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “A myriad of methods to determine temporal summation of pain in people with musculoskeletal pain and healthy participants: a scoping review” by @sjoerdkielstra et al. https://t.co/Jhm3FA3fpU https://t.co/61SEFWR4O9
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Mashup Score: 3
to provide insight into key elements of TSP stimulation and assessment: modality, instruments, test location, familiarization, train characteristics, and calculations. PubMed, Embase, and Ebsco/CINAHL were searched for studies that measured TSP in adults with musculoskeletal conditions and healthy people. Four hundred six studies were included. Mechanical stimuli were the most commonly used modality (250 studies), followed by thermal stimuli (125 studies). Forty-six different instruments were used. Disregarding studies on widespread musculoskeletal pain and healthy participants, 40 studies evaluated TSP at painful sites, 77 in remote areas, and 66 in both locations. Of the 13 tested locations in patients, the hand (74 studies), lower leg (64 studies), and forearm (59 studies) were most commonly tested. A single practice round was the most common familiarization method (46 studies). Repeated stimuli were applied using 31 different frequencies (0.03-200 Hz) and sustained stimulations ran
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “A myriad of methods to determine temporal summation of pain in people with musculoskeletal pain and healthy participants: a scoping review” by @sjoerdkielstra et al. https://t.co/Jhm3FA3fpU https://t.co/61SEFWR4O9
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Mashup Score: 2
hritis and anthropometric measures that include weight, height, and waist circumference. Methods: Using 4,602 participants (45–79 years) from the Osteoarthritis Initiative, we analyzed the association between knee osteoarthritis and anthropometry collectively and by sex. We calculated female and male tertiles (3 groups) for anthropometry. Results: Anthropometric measures were correlated with knee osteoarthritis (P ≤ 0.05) except the correlation between height and activities and height and quality of life. When comparing female weight tertiles, there were associations (P’s < 0.001) between knee osteoarthritis and weight, but when comparing male weight tertiles, these associations were primarily between the lowest weight and highest weight groups. There were significant associations between knee osteoarthritis and height among female tertiles, with no differences among male tertiles. There were knee osteoarthritis/waist circumference tertile associations (P's < 0.001) for the lowest and
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative” by Antoine et al. https://t.co/2pygURo0dD https://t.co/cthrVJGPxP
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Mashup Score: 2
hritis and anthropometric measures that include weight, height, and waist circumference. Methods: Using 4,602 participants (45–79 years) from the Osteoarthritis Initiative, we analyzed the association between knee osteoarthritis and anthropometry collectively and by sex. We calculated female and male tertiles (3 groups) for anthropometry. Results: Anthropometric measures were correlated with knee osteoarthritis (P ≤ 0.05) except the correlation between height and activities and height and quality of life. When comparing female weight tertiles, there were associations (P’s < 0.001) between knee osteoarthritis and weight, but when comparing male weight tertiles, these associations were primarily between the lowest weight and highest weight groups. There were significant associations between knee osteoarthritis and height among female tertiles, with no differences among male tertiles. There were knee osteoarthritis/waist circumference tertile associations (P's < 0.001) for the lowest and
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative” by Antoine et al. https://t.co/2pygURo0dD https://t.co/cthrVJGPxP
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Mashup Score: 2
hritis and anthropometric measures that include weight, height, and waist circumference. Methods: Using 4,602 participants (45–79 years) from the Osteoarthritis Initiative, we analyzed the association between knee osteoarthritis and anthropometry collectively and by sex. We calculated female and male tertiles (3 groups) for anthropometry. Results: Anthropometric measures were correlated with knee osteoarthritis (P ≤ 0.05) except the correlation between height and activities and height and quality of life. When comparing female weight tertiles, there were associations (P’s < 0.001) between knee osteoarthritis and weight, but when comparing male weight tertiles, these associations were primarily between the lowest weight and highest weight groups. There were significant associations between knee osteoarthritis and height among female tertiles, with no differences among male tertiles. There were knee osteoarthritis/waist circumference tertile associations (P's < 0.001) for the lowest and
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative” by Antoine et al. https://t.co/2pygURo0dD https://t.co/cthrVJGPxP
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Mashup Score: 0
derlying degenerative processes in LFJA. Objectives: This initial report describes the outcomes of the first treated patient in an ongoing mutidisciplinary phase 1 clinical trial evaluating the safety and feasibility of intra-articular allogeneic BM-MSCs for painful LFJA. Methods: Following enrollment in our IRB-approved protocol, symptomatic LFJA was confirmed through double blocks on L4 and L5 medial branches. Two 1-mL syringes, each containing 10 million BM-MSCs, were prepared in the cGMP facility and administered bilaterally to the patient’s L4-L5 lumbar facet joints. The patient underwent standardized follow-ups, including clinical examinations and functional and imaging assessments for 2 years, utilizing patient-reported outcomes measurement information system—computer adaptive tests (PROMIS CATs), visual analogue scale, Oswestry disability index, work functional status and opioid pain medication use, and MR imaging Fenton–Czervionke score. Results: The patient tolerated the proc
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Now in #PainReports: “CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow–derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy” by Dan Yan et al. https://t.co/oj51CUaSOT https://t.co/P67yYDZVuS
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Now in #PainReports: “Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference” by @Yaksh_YakshLab et al. https://t.co/TC2UzNxdwP https://t.co/2vrgtSmZTB