Lennard Y.W. LeeLennard Y.W. LeeCorrespondenceCorrespondence.AffiliationsDepartment of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UKInstitute of Cancer and Genomic Sciences, University of Birmingham, UKThomas StarkeyThomas StarkeyAffiliationsDepartment of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UKInstitute of Cancer and Genomic…
Pronounced necrosis in glioblastomas is accompanied by abundant destabilized microvessels. Wang et al. show that the niche cues from the peri-necrotic regions polarize macrophages toward a…
Liu et al. identify a novel feedforward loop between tumor cells and macrophages that promotes muscle wasting. Specifically, tumor-derived CCL2 activates macrophages to facilitate non-autonomous activation…
APOBEC3 cytidine deaminases have emerged as key drivers of mutagenesis in a wide spectrum of tumor types and are now appreciated to play a causal…
Ferroptosis-inducing therapies hold the potential in combating resistance to conventional treatments. Lei et al. discuss the role of ferroptosis in tumor suppression, its influence on the…
Yang et al. reveal the genomic and phenotypic inter- and intra-tumor heterogeneity of liver cancer using a biobank of 399 tumor organoids from 144 patients. Pharmacogenomic…
Network-based analyses of single-cell transcriptomes delineate B cell differentiation and its impact on leukemia drug sensitivity. Huang et al. uncover a correlation between developmental states and…
Lin et al. leverage a large-scale multi-omics cohort and a real-world clinical sequencing cohort to explore genetic interactions and their impact on treatment outcomes across various…
Di Chiaro et al. assign distinct transcriptional and functional programs to intratumor morphological variants that coexist in all pancreatic ductal adenocarcinomas (PDAC), providing a valuable resource…
mRNA has the potential to encode both vaccines and immunomodulatory proteins for cancer immunotherapy. In this issue, Beck et al. report on lipopolyplexed mRNAs encoding albumin-stabilized…
mRNA has the potential to encode both vaccines and immunomodulatory proteins for cancer immunotherapy. In this issue, Beck et al. report on lipopolyplexed mRNAs encoding albumin-stabilized…
