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Abstract. Several second- and third-line immunotherapeutic options for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) ineligible for autologous stem cell transplant are…
Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case–Control Study in Iran
AbstractBackground:. Limited data exist for the association between bladder cancers and waterpipe smoking, an emerging global public health concern.Methods:. We used the IROPICAN database in…
Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors
Abstract. 10% of pancreatic neuroendocrine tumors (pNETs) are related to inherited syndromes (MEN1, MEN4, VHL, NF1, TSC). Growing evidence suggests that clinically sporadic pNETs can…
Convergence Science | Cancer Research | American Association for Cancer Research
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EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Targeted degradation of EP300 with a novel PROTAC agent in neuroblastoma cells was found to cause widespread loss of gene expression and cell death in…
Reviewer Training Program | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research
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Antibody–Drug Conjugates: Advancing from Magic Bullet to Biological Missile
Summary. Precision drug development is focusing on targeting tumor cell surface proteins for therapeutic delivery, maximizing biomarker identified on-target damage to the tumor while minimizing…
Targeting Senescence for Next-Generation Cancer Treatments
Summary:. Cellular senescence has paradoxical effects on cancer emergence, progression, and therapeutic response. We herein identify four lessons that emerged from studying senescence interaction with…
Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers
Summary:. Beyond lipid membrane compartments, cells including cancer cells utilize various membraneless compartments, often termed biomolecular condensates, to regulate or organize key cellular processes underlying…
Accelerating Drug Development Using Spatial Multi-omics
Summary:. Spatial biology approaches enabled by innovations in imaging biomarker platforms and artificial intelligence–enabled data integration and analysis provide an assessment of patient and disease…