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Mashup Score: 48Telomeres: history, health, and hallmarks of aging - 18 hour(s) ago
Telomere attrition and dysfunction causes and consequences of cellular and molecular aging and age-related disease. Mounting data revel how telomeres are entwined with other aging hallmarks and may be therapeutic targets for aging and age-related disease.
Source: www.cell.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 36Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors - 1 day(s) ago
Abstract. 10% of pancreatic neuroendocrine tumors (pNETs) are related to inherited syndromes (MEN1, MEN4, VHL, NF1, TSC). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence of pathological/likely pathological germline variants (P/LP) in a high-risk cohort and an unselected cohort. We collected clinical data of patients with pNETs seen at MD Anderson Cancer Center (MDACC) and Johns Hopkins Hospital (JHH). High-risk cohort included (n=132) patients seen at MDACC who underwent germline testing for high-risk criteria (early onset, personal or family history of cancer and syndromic features) between 2013-2019. Unselected cohort (n=106) patients seen at JHH who underwent germline testing following their diagnosis of pNETs between 2020 to 2022. In the high-risk cohort (n=132), 33% (n=44) had P/LP variants. The majority of the patients had P/LP variants in MEN1 56% (n=25), followed by DNA repair pathway
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
In @CAPR_AACR from @hopkinskimmel & @MDAndersonNews #PancreaticCancer teams: Germline Testing identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors https://t.co/PPLsGC8wT4 In an unselected population, 1 in 5 harbor germline alterations⊠https://t.co/nb8IGxwIbU
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Mashup Score: 1OpenAI customer story: Moderna - 2 day(s) ago
Moderna and OpenAI partner to accelerate the development of life-saving treatments.
Source: openai.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 93Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma - 4 day(s) ago
Transcriptomic-based tumor microenvironment classification identifies 4 prognostically distinct pancreatic ductal adenocarcinoma subtypes that can serve as a framework for patient selection to precision medicine trials.
Source: www.gastrojournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 160Somatic Mutations in Normal Tissues: Calm before the Storm - 5 day(s) ago
Summary:. We explore the phenomenon of somatic mutations, including those in cancer driver genes, that are present in healthy, normal-appearing tissues and their potential implications for cancer development. We also examine the landscape of these somatic mutations, discuss the role of clonal cell competition and external factors like inflammation in enhancing the fitness of mutant clones, and conclude by considering how understanding these mutations will aid in prevention and/or interception of cancer.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 14
Under pressure from scientists to share more data on the H5N1 avian flu outbreaks in dairy cows, the USDA uploaded 239 genetic sequences of the virus.
Source: www.statnews.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 32
Under pressure from scientists to share more data on the H5N1 avian flu outbreaks in dairy cows, the USDA uploaded 239 genetic sequences of the virus.
Source: www.statnews.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 71
Under pressure from scientists to share more data on the H5N1 avian flu outbreaks in dairy cows, the USDA uploaded 239 genetic sequences of the virus.
Source: www.statnews.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 71âSmart toiletâ monitors for signs of disease - 5 day(s) ago
A disease-detecting âprecision healthâ toilet can sense multiple signs of illness through automated urine and stool analysis, a new Stanford study reports.
Source: med.stanford.eduCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 12
Under pressure from scientists to share more data on the H5N1 avian flu outbreaks in dairy cows, the USDA uploaded 239 genetic sequences of the virus.
Source: www.statnews.comCategories: General Medicine News, Hem/OncsTweet
Spectacular talk by @RonDePinho on telomeres in aging and cancer. Remarkable unpublished data đ€Ż Published review below for reference: https://t.co/MrwgmAtPlM https://t.co/cW4natOBBI