Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

Steroid hormones are essential in stress response, immune system regulation, and reproduction in mammals. Steroids with 3-oxo-delta-4 structure, such as testosterone, androstenedione, and progesterone, could be catalyzed by steroid 5-alpha reductases (SRD5As) to generate their corresponding 3-oxo-5-alpha steroids, which are essential for multiple physiological and pathological processes. Abnormal…