The degree of labeling (DOL) of antibodies has so far been optimized for high brightness and specific and efficient binding. The influence of the DOL on the blinking performance of antibodies used in direct stochastic optical reconstruction microscopy (dSTORM) has so far attained limited attention. Here, we investigated the spectroscopic characteristics of IgG antibodies labeled at DOLs of 1.1-…
Studies of benthic abundance and biodiversity are essential for fisheries management and environmental impact assessments. In the case of commercial species, such as Tehuelche scallop…
Current guidelines for treating vaccine-induced immune thrombotic thrombocytopenia (VITT) recommend non-heparin anticoagulants and intravenous immunoglobulin (IVIg). However, the efficacy of these treatments remains uncertain due…
The aquaculture industry has previously relied on high-quality fishmeal (FM) to produce diets of excellent standards. However, plant-based proteins such as soybean are more cost-effective…
Acute inflammation, characterized by a rapid influx of neutrophils, is a protective response that can lead to chronic inflammatory diseases when left unresolved. Secretion of…
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. To address these gaps and evaluate vaccine candidates, we established a human challenge…
This study investigates the impact of acute ischemic stroke on brain functional organization and evaluates the influence of temporal lag correction on connectivity gradients. Ischemic…
Amyloid-beta (Abeta)-directed antibodies tested clinically for therapeutic activity against Alzheimer disease (AD) have shown varying degrees of efficacy. Although all of these antibodies target the…
Cell-free systems are powerful synthetic biology technologies because of their ability to recapitulate sensing and gene expression without the complications of living cells. Cell-free systems…
The adaptor protein human GRB2 plays crucial roles in mediating signal transduction from cell membrane receptors to RAS and its downstream proteins by recruiting SOS1.…
Hidden Markov Model (HMM) inference for time-series data from ion channels or other biomolecules is challenging. We argue that inference on partially observed chemical reaction…
