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Mashup Score: 7Lupus Mesenteric Lymphadenitis - 11 day(s) ago
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Mashup Score: 52
Objective The objective of this study was to assess clinical laboratory parameters that distinguish between disease flare and infection in febrile patients with systemic lupus erythematosus (SLE) at…
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Can clinical labs distinguish between disease flare and infection in SLE patients with fever? EHR study found that ESR:CRP ratio + C3 & C4 levels and WBC, neutrophil, & monocyte counts could discriminate lupus flare from culture pos or neg infection ACROR https://t.co/P0nJqnHhwz https://t.co/vU97RjudKk
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Mashup Score: 8
Objective Despite extensive cancer-related research in patients with rheumatoid arthritis (RA), there remains a paucity of studies on thyroid cancer in RA patients. We investigated risk of thyroid c…
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Among >40k rheumatoid arthritis patients in the Korean NHID database, patients with newly diagnosed RA did not have increased risk of thyroid cancer compared to non-RA population. Thyroid cancer incidence was not affected by serologic status AC&R https://t.co/gwbnbqv4yi https://t.co/b5cBHTmEzy
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Mashup Score: 11A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis - 12 day(s) ago
Objective To compare the efficacy of abatacept to placebo for the treatment of relapsing, non-severe granulomatosis with polyangiitis (GPA). Methods In this multicenter trial, eligible patients wi…
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RCT assessed abatacept for treatment of relapsing, non-severe granulomatosis with polyangiitis compared to placebo. No statistical difference was found in the treatment failure rate, in time to full remission, or duration of GC-free remission A&R https://t.co/EpDuprkITd https://t.co/V7Kr94SB2b
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Mashup Score: 8Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation (GO‐GUT), an Early Remission Induction Study - 12 day(s) ago
Objective To evaluate the efficacy of tight-control, rapid escalation to TNF inhibition in early axial spondyloarthritis (axSpA) in relation to gut inflammation. Methods GO-GUT (NCT03270501) was a…
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Open-label trial assessed rapid escalation to golimumab (TNFi) in early axSpA gut inflammation. 73% of patients required escalation, of whom 55% achieved sustained remission. 78% of patients who discontinued treatment had disease relapse within 1 year A&R https://t.co/lPSmelBFn9 https://t.co/R0BDrAQc3M
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Mashup Score: 3Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways - 13 day(s) ago
Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fati…
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Mouse model explored how TRIM21 regulates local & sys. inflammation from UVB exposure. Loss of Trim21 was assoc. with ↑sensitivity to UVB, resulting in splenomegaly & induction of type I IFNs, reinforcing TRIM21 as neg. regulator of IFN-I response A&R https://t.co/Odj6yYxjQj https://t.co/hnMCbg2fLM
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Mashup Score: 75
Objective The objective of this study was to assess the clinical and histopathologic features of muscle vasculitis. Methods The electronic database of SA Pathology, wherein all muscle biopsy sampl…
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Muscle biopsies were examined to define phenotypes & features of muscle vasculitis. Patients w/ muscle vasculitis often had normal CK levels, and less weakness compared to IIM. Muscle vasculitis histology often lacked myofiber necrosis/infiltration ACROR https://t.co/FY7W29npsd https://t.co/1Y2mFQiZj3
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Mashup Score: 2
Objective This randomized, double-blind, adaptive phase II/III trial aimed to evaluate the efficacy and safety of ivarmacitinib, a novel selective JAK1 inhibitor, in patients with active ankylosing …
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Phase II/III trial assessed ivarmacitinib (JAK1 inhibitor) for active ankylosing spondylitis. Ivarmacitinib 4 mg showed improved ASAS20 response at wk 12 vs placebo, with efficacy sustained through 24 wks. Infection-related AEs were similar b/w groups A&R https://t.co/d5kOszlcxS https://t.co/4NzKxSMCpA
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Mashup Score: 4
Aim and objective This study explored the relationship between air pollution and rheumatoid arthritis (RA), focusing on how specific air quality components affect RA disease activity as measured by …
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Exploring the relationship between air quality and rheumatoid arthritis disease activity in Kuwait revealed associations between DAS28 scores and pollutants. In particular, NO₂ and O₃ were strong predictors of increased disease activity AC&R https://t.co/uj45SD3uFa https://t.co/5lfmbJkJuR
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Mashup Score: 0Editorial: The environment and Systemic Autoimmune Rheumatic Diseases (SARDS): What do we know after more than 15 years of research? - 15 day(s) ago
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Accompanying editorial on this study in Arthritis & Rheumatology: https://t.co/lq0FiWwiyr https://t.co/MezzEGsFWl
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Clinical images in Arthritis & Rheumatology https://t.co/1KtD8pAmfM