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Mashup Score: 2The Journal of Immunology - 10 month(s) ago
Read the current issue of The Journal of Immunology.
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Mashup Score: 1Efficacy of a Dual-Epitope Dendritic Cell Vaccine as Part of Combined Immunotherapy for HER2-Expressing Breast Tumors - 10 month(s) ago
Key Points. The combinatorial dual-epitope DC vaccine is safe.This vaccine regimen induced an immune response in a minority of patients.One patient had an excep
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Mashup Score: 2Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages - 10 month(s) ago
Key Points. LPS increased phagocytosis, NADPH oxidase activity, hypoxic signals, and inflammation.NAM increased NAD and posttranslational modifications to inhib
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Mashup Score: 1Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18 - 10 month(s) ago
Key Points. T-bet is required and sufficient to drive competitive liver CD4 TRM formation.T-bet drives CD18 expression on CD4 T cells.CD18 blockade ablated the
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Mashup Score: 5Targeted TLR9 Agonist Elicits Effective Antitumor Immunity against Spontaneously Arising Breast Tumors - 10 month(s) ago
Key Points. PIP-CpG is a systemically administered, tumor-targeting TLR9 agonist.PIP-CpG drives effective T cell–mediated immunity against spontaneous breast tu
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Mashup Score: 4Cutting Edge: Aire Is a Coactivator of the Vitamin D Receptor - 10 month(s) ago
Key Points. The Vdr is expressed in Aire+ medullary thymic epithelial cells.Thymic vitamin D signaling stimulates Aire expression and Aire-dependent gene transc
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Mashup Score: 0Considerations for Choosing T Cell Assays during a Pandemic - 10 month(s) ago
Abstract. The appropriate immunosurveillance tools are foundational for the creation of therapeutics, vaccines, and containment strategies when faced with outbr
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Mashup Score: 1Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice - 10 month(s) ago
Key Points. Nlrp3-specific ASO treatment downregulates Nlrp3 expression and IL-1β release in murine CAPS.Nlrp3-specific ASO treatment reduces systemic inflammat
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Mashup Score: 0Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements - 10 month(s) ago
Key Points. Th1 cells alter the transcriptional output of IL-6 during acute inflammation.IL-6 and IFN-γ activities combine to steer tissue responses to inflamma
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Mashup Score: 4SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor - 10 month(s) ago
Key Points. SARS-CoV-2 ORF8 but not IL-17 upregulates cytokines in monocytes/macrophages.Monocytes and macrophages infected with SARS-CoV-2 do not express IL-17
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The August 1, 2023 issue of The Journal of Immunology is now available online! #ReadTheJI 👉 https://t.co/wrOG9o0hPX https://t.co/dzMMvc1zr9